Transcription Factor

						

			
Accessions: SOX3 (HT-SELEX2 May2017)

			
Names: ENSG00000134595, SOX3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: HMG experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: HMG experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 446
Pfam Domains:   138-199 Domain of unknown function (DUF1898)
  139-207 HMG (high mobility group) box
  208-289 SOX transcription factor
Sequence: 
(in bold interface residues)		   1 MRPVRENSSGARSPRVPADLARSILISLPFPPDSLAHRPPSSAPTESQGLFTVAAPAPGA   60
  61 PSPPATLAHLLPAPAMYSLLETELKNPVGTPTQAAGTGGPAAPGGAGKSSANAAGGANSG  120
 121 GGSSGGASGGGGGTDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGADWKLL  180
 181 TDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKTKTLLKKDKYSLPSGLLPPGAAAAAAA  240
 241 AAAAAAAASSPVGVGQRLDTYTHVNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPPMH  300
 301 RYDMAGLQYSPMMPPGAQSYMNVAAAAAAASGYGGMAPSATAAAAAAYGQQPATAAAAAA  360
 361 AAAAMSLGPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAASPLPG  420
 421 GRLHGVHQHYQGAGTAVNGTVPLTHI
Interface Residues: 141, 144, 146, 147, 148, 150, 154, 165, 166, 167, 170, 208, 209, 212
3D-footprint Homologues: 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1ckt_A, 1hry_A, 3tq6_B
Binding Motifs: SOX3_2 sbcAMAATrk
SOX3_methyl_1 mkaACAATrs
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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