Transcription Factor

						

			
Accessions: NFIB_full (HumanTF 1.0)

			
Names: CCAAT-box-binding transcription factor, CTF, NF-I/B, NF1-B, NFI-B, NFIB, NFIB_HUMAN, Nuclear factor 1 B-type, Nuclear factor 1/B, Nuclear factor I/B, TGGCA-binding protein
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: O00712
Notes: Ensembl ID: ENSG00000147862; Full protein sequence; TF family: NFI; Clone source: hORFeome
Length: 571
Pfam Domains:      5-47 Nuclear factor I protein pre-N-terminus
   70-171 MH1 domain
  209-498 CTF/NF-I family transcription modulation region
Sequence: 
(in bold interface residues)		   1 MMYSPICLTQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE   60
  61 LLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDC  120
 121 LRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFL  180
 181 AYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFP  240
 241 IGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGS  300
 301 RTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTP  360
 361 PPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSG  420
 421 QVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASPTATTYTASGTSQA  480
 481 NRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQV  540
 541 SNRTPILPANVQNYGLNIIGEPFLQAETSN*
Interface Residues: 40, 43, 44, 48
3D-footprint Homologues: 2lkx_A
Binding Motifs: NFIB_full TTGGCAmmgTGCCAr
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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