Transcription Factor
| Accessions: | ZIC3_MOUSE (HOCOMOCO 10), Q62521 (JASPAR 2024) |
| Names: | ZIC3_MOUSE, Zinc finger protein of the cerebellum 3, Zinc finger protein ZIC 3 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q62521 |
| Length: | 466 |
| Pfam Domains: | 296-321 Zinc finger, C2H2 type 300-321 C2H2-type zinc finger 314-339 Zinc-finger double domain 327-351 C2H2-type zinc finger 327-351 Zinc finger, C2H2 type 343-370 Zinc-finger double domain 357-381 C2H2-type zinc finger 375-398 Zinc-finger double domain 387-409 Zinc finger, C2H2 type 387-409 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MTMLLDGGPQFPGLGVGSFGAPRHHEMPNREPAGMGLNPFGDSTHAAAAAAAAAAFKLSP 60 61 ATAHDLSSGQSSAFTPQGSGYANALGHHHHHHHHHHASQVPTYGGAASAAFNSTRDFLFR 120 121 QRGSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDN 180 181 NQVHLGLRGELFGRADPYRPVASPRTDPYAASAQFPNYSPMNMNMGVNVAAHHGPGAFFR 240 241 YMRQPIKQELSCKWIEEAQLSRPKKSCDRTFSTMHELVTHVTMEHVGGPEQNNHVCYWEE 300 301 CPREGKSFKAKYKLVNHIRVHTGEKPFPCPFPGCGKIFARSENLKIHKRTHTGEKPFKCE 360 361 FEGCDRRFANSSDRKKHMHVHTSDKPYICKVCDKSYTHPSSLRKHMKVHESQGSDSSPAA 420 421 SSGYESSTPPAIASANSKDTTKTPSAVQTSTSHNPGLPPNFNEWYV |
| Interface Residues: | 241, 242, 243, 273, 275, 276, 279, 309, 310, 311, 312, 313, 315, 316, 320, 327, 339, 340, 341, 342, 343, 345, 346, 347, 348, 349, 351, 352, 355, 364, 369, 370, 371, 372, 373, 374, 375, 376, 377, 380, 397, 398, 399, 400, 401, 402, 403, 404, 405 |
| 3D-footprint Homologues: | 5v3j_F, 6wmi_A, 5yel_A, 1ubd_C, 7w1m_H, 8cuc_F, 1tf3_A, 7n5w_A, 2gli_A, 1tf6_A, 8ssq_A, 6ml4_A, 4x9j_A, 5kkq_D, 8ssu_A, 5ei9_F, 8h9h_G, 7eyi_G, 6e94_A, 5k5i_A, 2lt7_A, 2i13_A, 7ysf_A, 8gn3_A, 2kmk_A, 3uk3_C, 6jnm_A, 7y3l_A, 5kl3_A, 1g2f_F, 6u9q_A, 5und_A, 1llm_D, 2v6e_B, 1mey_C, 6blw_A, 7y3m_I, 6a57_A, 2jpa_A, 6sjf_B, 5yj3_D, 7txc_E, 5k5l_F, 2wbs_A, 2drp_D, 1f2i_J, 4m9v_C |
| Binding Motifs: | PB0103.1 smCCCCCgGGGGggt PB0207.1 kwdCaCAGCAkGmsa ZIC3_MOUSE.H10MO.C|M01423 yGGGtGgyc MA0697.2 caCAGCAGGaggs MA0697.3 CAGCAGG |
| Binding Sites: | MA0697.2.1 MA0697.2.10 / MA0697.2.12 MA0697.2.11 MA0697.2.12 / MA0697.2.13 MA0697.2.13 / MA0697.2.15 MA0697.2.14 / MA0697.2.18 MA0697.2.15 / MA0697.2.19 MA0697.2.16 / MA0697.2.20 MA0697.2.17 MA0697.2.18 MA0697.2.19 MA0697.2.2 MA0697.2.20 MA0697.2.3 MA0697.2.4 MA0697.2.5 MA0697.2.6 MA0697.2.7 MA0697.2.8 MA0697.2.10 / MA0697.2.9 MA0697.2.11 MA0697.2.14 MA0697.2.16 MA0697.2.17 MA0697.2.9 MA0697.3.1 / MA0697.3.14 / MA0697.3.16 / MA0697.3.18 / MA0697.3.19 / MA0697.3.2 / MA0697.3.20 / MA0697.3.4 / MA0697.3.5 / MA0697.3.8 MA0697.3.10 / MA0697.3.3 MA0697.3.11 MA0697.3.12 MA0697.3.13 MA0697.3.15 MA0697.3.17 / MA0697.3.6 MA0697.3.7 MA0697.3.9 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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