Transcription Factor
| Accessions: | T148411_1.02 (CISBP 1.02), STAT2_HUMAN (HOCOMOCO 10), P52630 (JASPAR 2024) |
| Names: | STAT2, T148411_1.02;, p113, Signal transducer and activator of transcription 2, STAT2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P52630 |
| Notes: | experiment type:ChIP-seq, family:STAT |
| Length: | 851 |
| Pfam Domains: | 2-124 STAT protein, protein interaction domain 140-313 STAT protein, all-alpha domain 316-566 STAT protein, DNA binding domain 577-647 SH2 domain 783-838 Signal transducer and activator of transcription 2 C terminal |
| Sequence: (in bold interface residues) | 1 MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGSDDSKATMLF 60 61 FHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQPFSQDPTQLAEMIFNLLLEEKRILI 120 121 QAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRYKIQ 180 181 AKGKTPSLDPHQTKEQKILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKA 240 241 QQQKACIRAPIDHGLEQLETWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLTKGVDLR 300 301 NAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVE 360 361 VSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKG 420 421 PLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQ 480 481 NQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWAD 540 541 FTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLL 600 601 RFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENP 660 661 LRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKPEPELES 720 721 LELELGLVPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVIEPTLCMVSQTVPEPDQG 780 781 PVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEVYVSRPSHF 840 841 YTDGPLMPSDF |
| Interface Residues: | 335, 419, 457, 458, 459, 460, 461, 511, 514, 525, 538 |
| 3D-footprint Homologues: | 1bf5_A, 4y5w_B, 1bg1_A, 8hhl_A |
| Binding Motifs: | M4635_1.02 GRAAmyGAAACTgaa STAT2_HUMAN.H10MO.B|M01541 tcasTTTCrkTTyyc MA0517.1 tyAGTTTCrkTTYCy MA0517.2 AGTTTCrkTTYCy |
| Binding Sites: | MA0517.1.1 MA0517.1.10 MA0517.1.11 MA0517.1.12 MA0517.1.13 MA0517.1.14 MA0517.1.15 MA0517.1.16 MA0517.1.17 MA0517.1.18 MA0517.1.19 MA0517.1.2 MA0517.1.20 MA0517.1.3 MA0517.1.4 MA0517.1.5 MA0517.1.6 MA0517.1.7 MA0517.1.8 MA0517.1.9 MA0517.2.12 MA0517.2.1 MA0517.2.10 MA0517.2.11 MA0517.2.13 MA0517.2.14 MA0517.2.15 MA0517.2.16 MA0517.2.17 MA0517.2.18 MA0517.2.19 MA0517.2.2 MA0517.2.20 MA0517.2.3 MA0517.2.4 MA0517.2.5 MA0517.2.6 MA0517.2.7 MA0517.2.8 MA0517.2.9 |
| Publications: | Hartman S.E, Bertone P, Nath A.K, Royce T.E, Gerstein M, Weissman S, Snyder M. Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes & development 19:2953-68 (2005). [Pubmed] |
| Related annotations: | PaperBLAST |
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