Transcription Factor
| Accessions: | PAX1_DBD (HumanTF 1.0), PAX1_TF2 (HumanTF2 1.0), PAX1 (HT-SELEX2 May2017) |
| Names: | HuP48, Paired box protein Pax-1, PAX1, PAX1_HUMAN, ENSG00000125813 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P15863 |
| Notes: | Ensembl ID: ENSG00000125813; DNA-binding domain sequence; TF family: PAX; Clone source: Gene synthesis, Ensembl ID: ENSG00000125813; Construct type: TF2(3xFLAG); TF family: PAX; Clone source: Jolma et al. 2013, TF family: PAX experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: PAX experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 154 |
| Pfam Domains: | 4-127 'Paired box' domain 23-63 Homeodomain-like domain |
| Sequence: (in bold interface residues) | 1 EQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYN 60 61 ETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVS 120 121 SISRILRNKIGSLAQPGPYEASKQPPSQPTLPYN |
| Interface Residues: | 16, 48, 49, 51, 53, 54, 70, 73, 76, 118, 119, 120, 121, 123, 124, 127 |
| 3D-footprint Homologues: | 1k78_A, 1pdn_C, 6pax_A |
| Binding Motifs: | PAX1_DBD sGTCACGCwTSAsTGmm ELK1_PAX1 aCCGGAACyACGCwTsRsYg HOXB2_PAX1_1 ysGTCACGChyCATTdm HOXB2_PAX1_2 rymaTtaGTCACGCwTsrcTG PAX1_2 csGTCACGCwYsAcTGm PAX1_methyl_1 ysGTCACGCwTsAsyGm |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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