Transcription Factor

Accessions: HOXD1 (HT-SELEX2 May2017)
Names: ENSG00000128645, HOXD1
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 115
Pfam Domains: 31-84 Homeobox domain
Sequence:
(in bold interface residues)
1 STFEWMKVKRNASKKGKLAEYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEI 60
61 ANCLHLNDTQVKIWFQNRRMKQKKREREGLLATAIPVAPLQLPLSGTTPTKFIKN
Interface Residues: 25, 28, 30, 31, 69, 70, 72, 73, 76, 77, 80, 81, 84
3D-footprint Homologues: 6m3d_C, 1puf_A, 3d1n_M, 6a8r_A, 3cmy_A, 2hdd_A, 7q3o_C, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1fjl_B, 6es3_K, 4xrs_G, 2hos_A, 1nk2_P, 1b72_A, 5zfz_A, 4cyc_A, 1ig7_A, 5flv_I, 2ld5_A, 5zjt_E, 3a01_E, 2h1k_B, 1jgg_B, 7psx_B, 5hod_A, 3lnq_A, 2lkx_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1zq3_P, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4j19_B
Binding Motifs: HOXD1_3 sTAATTAs
HOXD1_methyl_1 sTAATTAs
HOXD1_methyl_2 rTCrTtAm
Related annotations: PaperBLAST

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