Transcription Factor
| Accessions: | 4f6n_A (3D-footprint 20231221), 6v8u_A (3D-footprint 20231221) |
| Names: | KAISO_HUMAN, Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q86T24 |
| Length: | 120 |
| Pfam Domains: | 28-51 Zinc-finger double domain 42-64 C2H2-type zinc finger 58-80 Zinc-finger double domain 70-93 C2H2-type zinc finger 70-93 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 DDHYELIVDGRVYYICIVCKRSYVCLTSLRRHFNIHSWEKKYPCRYCEKVFPLAEYRTKH 60 61 EIHHTGERRYQCLACGKSFINYQFMSSHIKSVHSQDPSGDSKLYRLHPCRSLQIRQYAYL 120 |
| Interface Residues: | 14, 24, 25, 26, 27, 28, 30, 31, 33, 34, 37, 52, 53, 54, 55, 56, 57, 58, 59, 60, 80, 81, 82, 83, 84, 85, 86, 87, 88, 91, 115, 117 |
| 3D-footprint Homologues: | 2kmk_A, 1tf3_A, 6ml4_A, 7n5w_A, 6jnm_A, 5k5i_A, 8ssu_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 6e94_A, 5kl3_A, 1ubd_C, 7ysf_A, 6wmi_A, 5ei9_F, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 7eyi_G, 5v3j_F, 8h9h_G, 2lt7_A, 6a57_A, 8gn3_A, 2jpa_A, 7y3l_A, 3uk3_C, 8cuc_F, 5yel_A, 1llm_D, 7txc_E, 2wbs_A, 1f2i_J, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | 4f6n_A gannnnGng 6v8u_A TGGCACGA |
| Binding Sites: | 4f6n_D 4f6n_E 6v8u_D 6v8u_E |
| Publications: | Buck-Koehntop B.A, Stanfield R.L, Ekiert D.C, Martinez-Yamout M.A, Dyson H.J, Wilson I.A, Wright P.E. Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso. Proceedings of the National Academy of Sciences of the United States of America 109:15229-34 (2012). [Pubmed] Nikolova EN, Stanfield RL, Dyson HJ, Wright PE. A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences. Biochemistry 59:1909-1926 (2020). [Pubmed] |
| Related annotations: | PaperBLAST |
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