Transcription Factor
| Accessions: | T025265_1.02 (CISBP 1.02), NF2L1_HUMAN (HOCOMOCO 10), Q14494 (JASPAR 2024) |
| Names: | NFE2L1, T025265_1.02;, Locus control region-factor 1, NF-E2-related factor 1, NF2L1_HUMAN, NFE2-related factor 1, Nuclear factor erythroid 2-related factor 1, Nuclear factor, erythroid derived 2, like 1, TCF-11, Transcription factor 11, Transcription factor HBZ17, Transcription factor LCR-F1, Endoplasmic reticulum membrane sensor NFE2L1, LCR-F1, Protein NRF1, p110 form, Protein NRF1, p120 form |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:bZIP |
| Length: | 772 |
| Pfam Domains: | 656-714 bZIP transcription factor 659-704 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIILGPSSAYTQTQFHNLRN 60 61 TLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNAWLVHRDPEGSVSGSQPNS 120 121 GLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVAPPVSGDLTKEDIDLIDILWR 180 181 QDIDLGAGREVFDYSHRQKEQDVEKELRDGGEQDTWAGEGAEALARNLLVDGETGESFPA 240 241 QVPSGEDQTALSLEECLRLLEATCPFGENAEFPADISSITEAVPSESEPPALQNNLLSPL 300 301 LTGTESPFDLEQQWQDLMSIMEMQAMEVNTSASEILYSAPPGDPLSTNYSLAPNTPINQN 360 361 VSLHQASLGGCSQDFLLFSPEVESLPVASSSTLLPLAPSNSTSLNSTFGSTNLTGLFFPP 420 421 QLNGTANDTAGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGLS 480 481 LDSSHSPSSLSSSEGSSSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAEG 540 541 AVGYQPEYSKFCRMSYQDPAQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSALKKGSK 600 601 EKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLIRDIRR 660 661 RGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQKVQSLYQE 720 721 VFGRLRDENGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRRK |
| Interface Residues: | 660, 664, 665, 667, 668, 671, 672, 675 |
| 3D-footprint Homologues: | 2wt7_A, 2wt7_B, 7x5e_E, 1skn_P, 4eot_A, 7x5e_F, 5t01_B, 5vpe_D, 2dgc_A |
| Binding Motifs: | M4030_1.02 skkvhwrvATGAC NF2L1_HUMAN.H10MO.C|M01353 mATGACk MA0089.2 avmATGACTCAGCAaw MA0089.3 ATGACTCAGCA |
| Binding Sites: | MA0089.2.1 MA0089.2.10 MA0089.2.10 / MA0089.2.11 MA0089.2.11 / MA0089.2.12 MA0089.2.13 MA0089.2.12 / MA0089.2.14 MA0089.2.13 / MA0089.2.15 MA0089.2.16 MA0089.2.14 / MA0089.2.17 MA0089.2.15 / MA0089.2.18 MA0089.2.16 / MA0089.2.19 MA0089.2.2 MA0089.2.17 / MA0089.2.20 MA0089.2.3 MA0089.2.4 MA0089.2.5 MA0089.2.6 MA0089.2.7 MA0089.2.8 MA0089.2.9 MA0089.2.18 MA0089.2.19 MA0089.2.20 MA0089.3.1 / MA0089.3.19 / MA0089.3.2 / MA0089.3.3 / MA0089.3.6 / MA0089.3.7 MA0089.3.10 / MA0089.3.13 MA0089.3.11 MA0089.3.12 MA0089.3.14 / MA0089.3.20 MA0089.3.15 MA0089.3.16 MA0089.3.17 MA0089.3.18 MA0089.3.4 MA0089.3.5 MA0089.3.8 / MA0089.3.9 |
| Publications: | Johnsen O., Murphy P., Prydz H., Kolsto A.-B. Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res. 26:512-520 (1998). [Pubmed] |
| Related annotations: | PaperBLAST |
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