Transcription Factor

						

			
Accessions: 1bdh_A (3D-footprint 20231221), 1qp7_A (3D-footprint 20231221), 1qqa_A (3D-footprint 20231221), 1qqb_A (3D-footprint 20231221)

			
Names: HTH-type transcriptional repressor PurR, Pur regulon repressor, Purine nucleotide synthesis repressor, PURINE REPRESSOR, PURR_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACP7
Length: 338
Pfam Domains:      1-46 Bacterial regulatory proteins, lacI family
   58-323 Periplasmic binding proteins and sugar binding domain of LacI family
   60-306 Periplasmic binding protein domain
  169-329 Periplasmic binding protein-like domain
Sequence: 
(in bold interface residues)		   1 TIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLAVNHTKSI   60
  61 GLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLLVM  120
 121 CSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHREIG  180
 181 VIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRPTA  240
 241 VFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGETAF  300
 301 NMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYR
Interface Residues: 2, 3, 12, 13, 14, 15, 17, 18, 24, 25, 26, 49, 52, 53
3D-footprint Homologues: 7ce1_D, 1efa_B, 3oqm_C, 1l1m_B, 1jft_A, 1zvv_A
Binding Motifs: 1qqa_A CGCangCg
1bdh_A / 1qqb_A CGcnnnCg
1qp7_A CGCannCg
Binding Sites: 1bdh_B
1qp7_M
1qqb_M
1qqa_M
			
Publications: Glasfeld A, Koehler A.N, Schumacher M.A, Brennan R.G. The role of lysine 55 in determining the specificity of the purine repressor for its operators through minor groove interactions. Journal of molecular biology 291:347-61 (1999). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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