Transcription Factor
| Accessions: | GATA1_HUMAN (HOCOMOCO 10), P15976 (JASPAR 2024) |
| Names: | Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GATA1_HUMAN, GF-1, NF-E1 DNA-binding protein |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 413 |
| Pfam Domains: | 204-237 GATA zinc finger 258-291 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL 60 61 AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA 120 121 VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL 180 181 NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP 240 241 LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD 300 301 GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT 360 361 AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS |
| Interface Residues: | 47, 213, 214, 216, 226, 230, 267, 268, 270, 280, 284, 285, 288, 305, 307, 308 |
| 3D-footprint Homologues: | 3zh2_C, 4hc9_A, 3vd6_C, 3dfx_B, 1gat_A, 4gat_A |
| Binding Motifs: | GATA1_HUMAN.H10MO.A|M01172 ckgkkrgrsaswGATAAGr MA0035.4 wtCTWATCTww MA0035.5 CTWATCT |
| Binding Sites: | MA0035.4.17 MA0035.4.18 / MA0035.4.7 MA0035.4.9 MA0035.4.1 MA0035.4.10 MA0035.4.11 MA0035.4.12 MA0035.4.13 MA0035.4.14 MA0035.4.15 / MA0035.4.5 MA0035.4.16 / MA0035.4.6 MA0035.4.19 / MA0035.4.8 MA0035.4.2 MA0035.4.20 MA0035.4.3 MA0035.4.4 MA0035.4.5 MA0035.4.3 / MA0035.4.6 MA0035.4.7 MA0035.4.8 MA0035.4.4 / MA0035.4.9 MA0035.4.10 MA0035.4.11 MA0035.4.12 MA0035.4.13 MA0035.4.14 MA0035.4.15 MA0035.4.16 MA0035.4.17 MA0035.4.18 MA0035.4.19 MA0035.4.2 MA0035.4.20 MA0035.5.1 MA0035.5.10 MA0035.5.11 / MA0035.5.18 / MA0035.5.3 / MA0035.5.7 MA0035.5.12 / MA0035.5.16 MA0035.5.13 MA0035.5.14 MA0035.5.15 MA0035.5.17 / MA0035.5.19 / MA0035.5.20 / MA0035.5.5 / MA0035.5.6 / MA0035.5.9 MA0035.5.2 MA0035.5.4 MA0035.5.8 |
| Publications: | Chen Y, Bates D.L, Dey R, Chen P.H, Machado A.C, Laird-Offringa I.A, Rohs R, Chen L. DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell reports 2:1197-206 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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