Transcription Factor

Accessions: BATF3_DBD (HumanTF 1.0), BATF3 (HT-SELEX2 May2017)
Names: 21 kDa small nuclear factor isolated from T-cells, B-ATF-3, Basic leucine zipper transcriptional factor ATF-like 3, BATF3, BATF3_HUMAN, Jun dimerization protein p21SNFT, ENSG00000123685
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HT-SELEX2 May2017 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Uniprot: Q9NR55
Notes: Ensembl ID: ENSG00000123685; DNA-binding domain sequence; TF family: bZIP; Clone source: Megaman, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 112
Pfam Domains: 31-91 bZIP transcription factor
32-85 Basic region leucine zipper
Sequence:
(in bold interface residues)
1 QGLPAAGSVLQRSVAAPGNQPQPQPQQQSPEDDDRKVRRREKNRVAAQRSRKKQTQKADK 60
61 LHEEYESLEQENTMLRREIGKLTEELKHLTEALKEHEKMCPLLLCPMNFVPV
Interface Residues: 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 54, 56
3D-footprint Homologues: 4eot_A, 6mg1_B, 7x5e_F, 1skn_P, 1nwq_C, 5t2h_A, 5t01_B, 2c9l_Z, 5vpe_D, 1dh3_C
Binding Motifs: BATF3_DBD TGATGACGTCATCr
BATF3_2 grTGACGTCAyc
BATF3_4 grTGACGTCAys
BATF3_methyl_1 gaTGAyGTCAyc
BATF3_methyl_3 grTGAyGTCAyc
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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