Transcription Factor

Accessions: UP00610D (UniPROBE 20160601)
Names: KPD, MGC129960, MODY9, paired box protein Pax-4, PAX4_R192S
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: paired box protein Pax-4: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
Length: 218
Pfam Domains: 1-103 'Paired box' domain
146-201 Homeobox domain
Sequence:
(in bold interface residues)
1 RQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVA 60
61 RIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPA 120
121 VLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVASGKLATA 180
181 TSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGL
Interface Residues: 24, 25, 27, 29, 30, 46, 49, 52, 94, 95, 96, 97, 99, 100, 103, 143, 145, 146, 147, 148, 186, 187, 189, 190, 193, 194, 197, 198, 201
3D-footprint Homologues: 6pax_A, 1k78_A, 1pdn_C, 1mnm_C, 1puf_A, 3d1n_M, 5zfz_A, 1le8_B, 1k61_B, 3lnq_A, 2lkx_A, 1nk2_P, 1jgg_B, 1zq3_P, 6es3_K, 7q3o_C, 2ld5_A, 1fjl_B, 5hod_A, 6a8r_A, 1b72_A, 3cmy_A, 2hdd_A, 7psx_B, 1ig7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 1au7_A, 3a01_E, 2h1k_B, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 8g87_X, 4qtr_D, 1du0_A, 1o4x_A, 4j19_B
Binding Motifs: UP00610D_1 varwsgcytAATTarkccmwwk
UP00610D_2 aakwgshyTAATTArygsackw
Binding Sites: AATTAATT
AATTAGTG
ACTAATTA
ATAATTAG
ATTAATTA
ATTAATTG
CAAATTAA
CAATTAAG
CCAATTAA
CCTAATTA
CTAATTAA
CTAATTAG
CTTAATTA
GCTAATTA
GTAATTAA
GTTAATTA
TAATTAAA
TAATTAGA
TTAATTAA
AAATTAAG
AATTAACA
AATTAAGA
ATTAATCG
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.