Transcription Factor
| Accessions: | O75467 (JASPAR 2024) |
| Names: | Z324A_HUMAN, Zinc finger protein 324A, Zinc finger protein ZF5128 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O75467 |
| Length: | 553 |
| Pfam Domains: | 2-41 KRAB box 251-267 Zinc-finger double domain 257-279 Zinc finger, C2H2 type 257-279 C2H2-type zinc finger 257-279 C2H2-type zinc finger 271-295 Zinc-finger double domain 284-305 C2H2-type zinc finger 285-307 Zinc finger, C2H2 type 285-307 C2H2-type zinc finger 299-324 Zinc-finger double domain 313-335 Zinc finger, C2H2 type 313-335 C2H2-type zinc finger 313-333 C2H2-type zinc finger 327-352 Zinc-finger double domain 341-362 C2H2-type zinc finger 341-361 C2H2-type zinc finger 341-363 Zinc finger, C2H2 type 355-378 Zinc-finger double domain 369-391 C2H2-type zinc finger 369-391 C2H2-type zinc finger 369-391 Zinc finger, C2H2 type 384-407 Zinc-finger double domain 397-419 C2H2-type zinc finger 397-419 C2H2-type zinc finger 397-419 Zinc finger, C2H2 type 412-436 Zinc-finger double domain 425-447 Zinc finger, C2H2 type 425-447 C2H2-type zinc finger 425-444 C2H2-type zinc finger 439-463 Zinc-finger double domain 453-475 Zinc finger, C2H2 type 453-473 C2H2-type zinc finger 468-490 Zinc-finger double domain 481-503 Zinc finger, C2H2 type 481-503 C2H2-type zinc finger 481-501 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPW 60 61 VPSGTDTTLSRTTYRRRNPGSWSLTEDRDVSGEWPRAFPDTPPGMTTSVFPVAGACHSVK 120 121 SLQRQRGASPSRERKPTGVSVIYWERLLLGSGSGQASVSLRLTSPLRPPEGVRLREKTLT 180 181 EHALLGRQPRTPERQKPCAQEVPGRTFGSAQDLEAAGGRGHHRMGAVWQEPHRLLGGQEP 240 241 STWDELGEALHAGEKSFECRACSKVFVKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHL 300 301 TQHQRIHSGETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECGKAFSHGSNLSQHR 360 361 KIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFKHQRVHT 420 421 GEKPFACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFAKGAVLLSHRRIHTGEKP 480 481 FVCTQCGRAFRERPALFHHQRIHTGEKTVRRSRASLHPQARSVAGASSEGAPAKETEPTP 540 541 ASGPAAVSQPAEV |
| Interface Residues: | 257, 267, 268, 269, 270, 271, 273, 274, 295, 296, 297, 298, 299, 302, 303, 309, 310, 324, 325, 326, 327, 328, 330, 331, 333, 334, 352, 353, 354, 355, 358, 379, 380, 382, 383, 385, 386, 388, 389, 392, 407, 408, 409, 410, 411, 412, 413, 414, 435, 436, 437, 438, 439, 441, 442, 464, 465, 466, 467, 470, 476, 490, 491, 492, 494, 495, 498, 502 |
| 3D-footprint Homologues: | 2kmk_A, 7n5w_A, 8ssu_A, 6u9q_A, 2drp_D, 8ssq_A, 1tf6_A, 7w1m_H, 5und_A, 5k5l_F, 8h9h_G, 7eyi_G, 7y3m_I, 1ubd_C, 5v3j_F, 2i13_A, 5yj3_D, 1llm_D, 4m9v_C, 5yel_A, 1yuj_A, 8gn3_A, 5kkq_D, 7ysf_A, 6wmi_A, 2gli_A, 3uk3_C, 6jnm_A, 6ml4_A, 4x9j_A, 6blw_A, 1f2i_J, 5ei9_F, 5kl3_A, 1g2f_F, 6a57_A, 2jpa_A, 7y3l_A, 1tf3_A, 8cuc_F, 1mey_C, 2wbs_A, 7txc_E, 5k5i_A, 2lt7_A, 6e94_A |
| Binding Motifs: | MA1977.1 dmswrgmAGmyAAGGATGGYT MA1977.2 AGmyAAGGATGGYT |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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