Transcription Factor

Accessions: T044227_1.02 (CISBP 1.02), PRDM1_HUMAN (HOCOMOCO 10), O75626 (JASPAR 2024)
Names: PRDM1, T044227_1.02;, Beta-interferon gene positive regulatory domain I-binding factor, BLIMP-1, EC 2.1.1.-, Positive regulatory domain I-binding factor 1, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1, PRDI-binding factor 1, PRDM1_HUMAN
Organisms: Homo sapiens
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: O75626
Notes: experiment type:ChIP-seq, family:C2H2 ZF
Length: 825
Pfam Domains: 100-200 SET domain
575-597 Zinc finger, C2H2 type
575-597 C2H2-type zinc finger
589-613 Zinc-finger double domain
603-625 C2H2-type zinc finger
603-625 Zinc finger, C2H2 type
617-642 Zinc-finger double domain
631-653 C2H2-type zinc finger
631-653 Zinc finger, C2H2 type
645-669 Zinc-finger double domain
659-681 C2H2-type zinc finger
Sequence:
(in bold interface residues)
1 MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY 60
61 IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI 120
121 YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM 180
181 NIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP 240
241 KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP 300
301 IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV 360
361 SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM 420
421 NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ 480
481 PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA 540
541 PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE 600
601 RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ 660
661 CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL 720
721 EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM 780
781 GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP
Interface Residues: 540, 542, 547, 548, 551, 564, 575, 585, 586, 587, 588, 589, 591, 592, 593, 596, 605, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 626, 628, 641, 642, 643, 644, 645, 647, 648, 651, 670, 671, 672, 673, 675, 676, 698, 699, 700, 701, 702, 703, 704
3D-footprint Homologues: 5v3j_F, 2i13_A, 6wmi_A, 7w1m_H, 2kmk_A, 1tf3_A, 6jnm_A, 8cuc_F, 6u9q_A, 5ei9_F, 8ssq_A, 1tf6_A, 5k5l_F, 8ssu_A, 8gn3_A, 5kkq_D, 4m9v_C, 7y3m_I, 6e94_A, 7ysf_A, 2lt7_A, 5yel_A, 6a57_A, 1ubd_C, 2gli_A, 7n5w_A, 7txc_E, 5kl3_A, 2drp_D, 1g2f_F, 5und_A, 6ml4_A, 4x9j_A, 1mey_C, 6blw_A, 2wbs_A, 8h9h_G, 7eyi_G, 2jpa_A, 1yuj_A, 3uk3_C, 7y3l_A, 1f2i_J, 5k5i_A, 1llm_D, 5yj3_D
Binding Motifs: MA0508.1 wrAAAGtGAAAGTga
M4545_1.02 wraAAGtGAAAGTga
PRDM1_HUMAN.H10MO.C|M01462 raAAGtGAAAGTga
MA0508.2 tcACTTTCwc
MA0508.3 ywCTTTCTCty
MA0508.4 CTTTCTC
Binding Sites: MA0508.1.1
MA0508.1.10
MA0508.1.11
MA0508.1.12
MA0508.1.13
MA0508.1.14
MA0508.1.15
MA0508.1.16
MA0508.1.17
MA0508.1.18
MA0508.1.19
MA0508.1.2
MA0508.1.20
MA0508.1.3
MA0508.1.4
MA0508.1.5
MA0508.1.6
MA0508.1.7
MA0508.1.8
MA0508.1.9
MA0508.2.1
MA0508.2.10
MA0508.2.11 / MA0508.2.12
MA0508.2.13
MA0508.2.14
MA0508.2.15
MA0508.2.16 / MA0508.2.20
MA0508.2.17
MA0508.2.18
MA0508.2.19
MA0508.2.2 / MA0508.2.7
MA0508.2.3
MA0508.2.4
MA0508.2.5
MA0508.2.6
MA0508.2.8
MA0508.2.9
MA0508.3.1
MA0508.3.10
MA0508.3.11 / MA0508.3.4
MA0508.3.12 / MA0508.3.5
MA0508.3.13
MA0508.3.14 / MA0508.3.6
MA0508.3.15
MA0508.3.16
MA0508.3.17
MA0508.3.18
MA0508.3.19
MA0508.3.1 / MA0508.3.2
MA0508.3.20 / MA0508.3.7
MA0508.3.3
MA0508.3.2 / MA0508.3.4
MA0508.3.5
MA0508.3.6
MA0508.3.3 / MA0508.3.7
MA0508.3.8
MA0508.3.9
MA0508.3.10
MA0508.3.11
MA0508.3.12
MA0508.3.13
MA0508.3.14
MA0508.3.15
MA0508.3.16
MA0508.3.17
MA0508.3.18
MA0508.3.19
MA0508.3.20
MA0508.3.8
MA0508.3.9
MA0508.4.1 / MA0508.4.10 / MA0508.4.15 / MA0508.4.16 / MA0508.4.18 / MA0508.4.2 / MA0508.4.20 / MA0508.4.3 / MA0508.4.6 / MA0508.4.7
MA0508.4.11
MA0508.4.12
MA0508.4.13
MA0508.4.14
MA0508.4.17 / MA0508.4.4 / MA0508.4.9
MA0508.4.19
MA0508.4.5
MA0508.4.8
Publications: Doody G.M, Care M.A, Burgoyne N.J, Bradford J.R, Bota M, Bonifer C, Westhead D.R, Tooze R.M. An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic acids research 38:5336-50 (2010). [Pubmed]

Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.