Transcription Factor
| Accessions: | T044227_1.02 (CISBP 1.02), PRDM1_HUMAN (HOCOMOCO 10), O75626 (JASPAR 2024) |
| Names: | PRDM1, T044227_1.02;, Beta-interferon gene positive regulatory domain I-binding factor, BLIMP-1, EC 2.1.1.-, Positive regulatory domain I-binding factor 1, PR domain zinc finger protein 1, PR domain-containing protein 1, PRDI-BF1, PRDI-binding factor 1, PRDM1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O75626 |
| Notes: | experiment type:ChIP-seq, family:C2H2 ZF |
| Length: | 825 |
| Pfam Domains: | 100-200 SET domain 575-597 C2H2-type zinc finger 575-597 Zinc finger, C2H2 type 589-613 Zinc-finger double domain 603-625 C2H2-type zinc finger 603-625 Zinc finger, C2H2 type 617-642 Zinc-finger double domain 631-653 C2H2-type zinc finger 631-653 Zinc finger, C2H2 type 645-669 Zinc-finger double domain 659-681 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTY 60 61 IVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEI 120 121 YTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGM 180 181 NIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCP 240 241 KNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYP 300 301 IRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTV 360 361 SPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGM 420 421 NCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ 480 481 PEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAA 540 541 PSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGE 600 601 RPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQ 660 661 CKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPL 720 721 EDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNM 780 781 GNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP |
| Interface Residues: | 540, 542, 547, 548, 551, 564, 575, 585, 586, 587, 588, 589, 591, 592, 593, 596, 605, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 626, 628, 641, 642, 643, 644, 645, 647, 648, 651, 670, 671, 672, 673, 675, 676, 698, 699, 700, 701, 702, 703, 704 |
| 3D-footprint Homologues: | 5v3j_F, 2i13_A, 6wmi_A, 7w1m_H, 2kmk_A, 1tf3_A, 6jnm_A, 8cuc_F, 5k5l_F, 8ssu_A, 8gn3_A, 5kkq_D, 6u9q_A, 5ei9_F, 8ssq_A, 1tf6_A, 4m9v_C, 2lt7_A, 7y3m_I, 6e94_A, 7ysf_A, 6a57_A, 5yel_A, 1ubd_C, 2gli_A, 7n5w_A, 6ml4_A, 4x9j_A, 1mey_C, 6blw_A, 2wbs_A, 7txc_E, 5kl3_A, 2drp_D, 1g2f_F, 5und_A, 8h9h_G, 7eyi_G, 2jpa_A, 1yuj_A, 7y3l_A, 3uk3_C, 1f2i_J, 5k5i_A, 1llm_D, 5yj3_D |
| Binding Motifs: | MA0508.1 wrAAAGtGAAAGTga M4545_1.02 wraAAGtGAAAGTga PRDM1_HUMAN.H10MO.C|M01462 raAAGtGAAAGTga MA0508.2 tcACTTTCwc MA0508.3 ywCTTTCTCty MA0508.4 CTTTCTC |
| Binding Sites: | MA0508.1.1 MA0508.1.10 MA0508.1.11 MA0508.1.12 MA0508.1.13 MA0508.1.14 MA0508.1.15 MA0508.1.16 MA0508.1.17 MA0508.1.18 MA0508.1.19 MA0508.1.2 MA0508.1.20 MA0508.1.3 MA0508.1.4 MA0508.1.5 MA0508.1.6 MA0508.1.7 MA0508.1.8 MA0508.1.9 MA0508.2.1 MA0508.2.10 MA0508.2.11 / MA0508.2.12 MA0508.2.13 MA0508.2.14 MA0508.2.15 MA0508.2.16 / MA0508.2.20 MA0508.2.17 MA0508.2.18 MA0508.2.19 MA0508.2.2 / MA0508.2.7 MA0508.2.3 MA0508.2.4 MA0508.2.5 MA0508.2.6 MA0508.2.8 MA0508.2.9 MA0508.3.1 MA0508.3.10 MA0508.3.11 / MA0508.3.4 MA0508.3.12 / MA0508.3.5 MA0508.3.13 MA0508.3.14 / MA0508.3.6 MA0508.3.15 MA0508.3.16 MA0508.3.17 MA0508.3.18 MA0508.3.19 MA0508.3.1 / MA0508.3.2 MA0508.3.20 / MA0508.3.7 MA0508.3.3 MA0508.3.2 / MA0508.3.4 MA0508.3.5 MA0508.3.6 MA0508.3.3 / MA0508.3.7 MA0508.3.8 MA0508.3.9 MA0508.3.10 MA0508.3.11 MA0508.3.12 MA0508.3.13 MA0508.3.14 MA0508.3.15 MA0508.3.16 MA0508.3.17 MA0508.3.18 MA0508.3.19 MA0508.3.20 MA0508.3.8 MA0508.3.9 MA0508.4.1 / MA0508.4.10 / MA0508.4.15 / MA0508.4.16 / MA0508.4.18 / MA0508.4.2 / MA0508.4.20 / MA0508.4.3 / MA0508.4.6 / MA0508.4.7 MA0508.4.11 MA0508.4.12 MA0508.4.13 MA0508.4.14 MA0508.4.17 / MA0508.4.4 / MA0508.4.9 MA0508.4.19 MA0508.4.5 MA0508.4.8 |
| Publications: | Doody G.M, Care M.A, Burgoyne N.J, Bradford J.R, Bota M, Bonifer C, Westhead D.R, Tooze R.M. An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression. Nucleic acids research 38:5336-50 (2010). [Pubmed] Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.