Transcription Factor

						

			
Accessions: 6fqq_B (3D-footprint 20231221), 6fqq_E (3D-footprint 20231221)

			
Names: 5'-TG-3'-interacting factor 1, Homeobox protein TGIF1, TGIF1_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q15583
Length: 61
Pfam Domains:     14-53 Homeobox KN domain
    16-53 Homeobox domain
Sequence: 
(in bold interface residues)		   1 GNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLR   60
  61 K
Interface Residues: 44, 45, 48, 49, 50, 52, 53
3D-footprint Homologues: 4j19_B, 1le8_A, 5zjt_E, 2d5v_B, 1fjl_B, 1mnm_C, 6fqp_B, 2hdd_A, 1k61_B, 4xrm_B, 1puf_B, 6fqq_E, 4xrs_G, 1zq3_P, 1du0_A, 7psx_B, 3a01_E, 1le8_B, 2hos_A
Binding Motifs: 6fqq_AB tGACAgnTGTCA
6fqq_DE TGACAGCTGKCA
6fqq_E tGACAg
Binding Sites: 6fqq_G / 6fqq_H / 6fqq_L / 6fqq_M
			
Publications: Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. Nucleic Acids Res 46:9220-9235 (2018). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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