Transcription Factor
| Accessions: | ZIC2_MOUSE (HOCOMOCO 10), Q62520 (JASPAR 2024) |
| Names: | ZIC2_MOUSE, Zinc finger protein of the cerebellum 2, Zinc finger protein ZIC 2 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q62520 |
| Length: | 530 |
| Pfam Domains: | 273-291 C2H2-type zinc finger 320-345 Zinc-finger double domain 333-357 Zinc finger, C2H2 type 333-357 C2H2-type zinc finger 349-376 Zinc-finger double domain 363-387 C2H2-type zinc finger 381-404 Zinc-finger double domain 393-415 C2H2-type zinc finger 393-415 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAF 60 61 KLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFL 120 121 FRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPPEQHGPHASQNVLNGQM 180 181 RLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHP 240 241 GAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNH 300 301 VCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGE 360 361 KPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQ 420 421 GSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGAGS 480 481 GSSGSGGGSAAGSGGGGGGAGGGGGGSSGGGSGTTGGHSGLSSNFNEWYV |
| Interface Residues: | 278, 279, 281, 282, 285, 315, 316, 317, 318, 319, 322, 326, 345, 346, 347, 348, 349, 351, 352, 353, 354, 355, 357, 358, 361, 375, 376, 377, 378, 379, 380, 381, 382, 383, 386, 403, 404, 405, 406, 407, 408, 409, 410, 411, 434, 435 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 1tf3_A, 7w1m_H, 8cuc_F, 7n5w_A, 5ei9_F, 2gli_A, 8ssq_A, 1tf6_A, 8ssu_A, 6ml4_A, 4x9j_A, 8gn3_A, 5kkq_D, 7eyi_G, 6e94_A, 7ysf_A, 6wmi_A, 5k5i_A, 2i13_A, 5und_A, 3uk3_C, 6jnm_A, 7y3l_A, 6u9q_A, 5yel_A, 2kmk_A, 5kl3_A, 1g2f_F, 1llm_D, 2v6e_B, 1mey_C, 6blw_A, 8h9h_G, 7y3m_I, 2lt7_A, 6a57_A, 2jpa_A, 2drp_D, 1f2i_J, 7txc_E, 5yj3_D, 5k5l_F, 2wbs_A, 4m9v_C |
| Binding Motifs: | PB0102.1 bmCCCCCgGGGGggt PB0206.1 ycdCvCAGCAkGara ZIC2_MOUSE.H10MO.C|M01422 kGGGtGGTc MA1628.1 cvCAGCAGGsr MA1629.1 mkCaCAGCAGGrrg MA1628.2 CAGCAGG MA1629.2 CaCAGCAGG |
| Binding Sites: | MA1628.1.1 MA1628.1.10 MA1628.1.11 MA1628.1.12 / MA1628.1.9 MA1628.1.10 / MA1628.1.13 MA1628.1.11 / MA1628.1.14 MA1628.1.15 MA1628.1.12 / MA1628.1.16 MA1628.1.13 / MA1628.1.17 MA1628.1.14 / MA1628.1.18 MA1628.1.15 / MA1628.1.19 MA1628.1.2 MA1628.1.16 / MA1628.1.20 MA1628.1.3 / MA1628.1.4 / MA1628.1.6 MA1628.1.5 MA1628.1.7 MA1628.1.7 / MA1628.1.8 MA1628.1.8 / MA1628.1.9 MA1629.1.1 MA1629.1.10 / MA1629.1.5 MA1629.1.11 / MA1629.1.7 MA1629.1.12 / MA1629.1.8 MA1629.1.13 / MA1629.1.9 MA1629.1.10 / MA1629.1.14 MA1629.1.15 MA1629.1.11 / MA1629.1.16 MA1629.1.17 MA1629.1.18 MA1629.1.12 / MA1629.1.19 MA1629.1.1 / MA1629.1.2 MA1629.1.20 MA1629.1.3 MA1629.1.4 MA1629.1.5 MA1629.1.2 / MA1629.1.6 MA1629.1.7 MA1629.1.8 MA1629.1.4 / MA1629.1.9 MA1628.1.17 MA1628.1.18 MA1628.1.19 MA1628.1.20 MA1629.1.13 MA1629.1.14 MA1629.1.15 MA1629.1.16 MA1629.1.17 MA1629.1.18 MA1629.1.19 MA1629.1.20 MA1629.1.3 MA1629.1.6 MA1628.2.1 / MA1628.2.10 / MA1628.2.11 / MA1628.2.12 / MA1628.2.13 / MA1628.2.14 / MA1628.2.15 / MA1628.2.16 / MA1628.2.17 / MA1628.2.18 / MA1628.2.19 / MA1628.2.2 / MA1628.2.20 / MA1628.2.3 / MA1628.2.4 / MA1628.2.5 / MA1628.2.6 / MA1628.2.7 / MA1628.2.8 / MA1628.2.9 MA1629.2.1 / MA1629.2.19 / MA1629.2.5 MA1629.2.10 / MA1629.2.15 MA1629.2.11 / MA1629.2.17 / MA1629.2.7 MA1629.2.12 MA1629.2.13 / MA1629.2.8 MA1629.2.14 MA1629.2.16 MA1629.2.18 MA1629.2.2 / MA1629.2.9 MA1629.2.20 MA1629.2.3 MA1629.2.4 MA1629.2.6 |
| Publications: | Salero E., Perez-Sen R., Aruga J., Gimenez C., Zafra F. Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. J. Biol. Chem. 276:1881-1888 (2001). [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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