Transcription Factor

						

			
Accessions: PAX7_full (HumanTF 1.0)

			
Names: HuP1, Paired box protein Pax-7, PAX7, PAX7_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: P23759
Notes: Ensembl ID: ENSG00000009709; Full protein sequence; TF family: PAX+Homeodomain; Clone source: hORFeome
Length: 521
Pfam Domains:    34-161 'Paired box' domain
  218-274 Homeobox domain
  241-271 Homeobox KN domain
  345-385 Paired box protein 7 
Sequence: 
(in bold interface residues)		   1 MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIV   60
  61 EMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPRQVATPDVEKKIEE  120
 121 YKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLVSSISRVLRIKFGKKEEEDEADKKEDDG  180
 181 EKKAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTH  240
 241 YPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTL  300
 301 PPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSS  360
 361 YSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSIS  420
 421 ASCSQRADSIKPGDSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQSECLVPWASPVPI  480
 481 PSPTPRASCLFMESYKVVSGWGMSISQMEKLKSSQMEQFT*
Interface Residues: 47, 79, 80, 82, 84, 85, 101, 104, 107, 150, 153, 154, 155, 157, 158, 161, 217, 218, 219, 220, 221, 259, 260, 262, 263, 266, 267, 269, 270, 271, 273, 274
3D-footprint Homologues: 1pdn_C, 6pax_A, 1k78_A, 4j19_B, 6a8r_A, 3d1n_M, 2h1k_B, 1fjl_B, 1puf_A, 5zfz_A, 6fqp_B, 1ig7_A, 3cmy_A, 1zq3_P, 6m3d_C, 2lkx_A, 1nk2_P, 3lnq_A, 1jgg_B, 7q3o_C, 2ld5_A, 6es3_K, 5jlw_D, 4cyc_A, 1au7_A, 4xrs_G, 3l1p_A, 1b72_A, 3a01_E, 2hdd_A, 5flv_I, 2r5y_A, 1puf_B, 7psx_B, 5zjt_E, 2hos_A, 5hod_A, 3rkq_B, 1e3o_C, 7xrc_C, 1le8_A, 2xsd_C, 1le8_B, 4xrm_B, 1k61_B, 1mnm_C, 8g87_X, 4qtr_D, 1du0_A, 1o4x_A, 6fqq_E, 2ypa_A
Binding Motifs: PAX7_full TAATCRATTA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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