Transcription Factor
| Accessions: | ZEB1_HUMAN (HOCOMOCO 10), P37275 (JASPAR 2024) |
| Names: | Negative regulator of IL2, NIL-2-A zinc finger protein, TCF-8, Transcription factor 8, ZEB1_HUMAN, Zinc finger E-box-binding homeobox 1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 1125 |
| Pfam Domains: | 171-193 C2H2-type zinc finger 171-193 Zinc finger, C2H2 type 184-211 Zinc-finger double domain 200-222 Zinc finger, C2H2 type 200-224 C2H2-type zinc finger 200-222 C2H2-type zinc finger 200-223 Zinc-finger of C2H2 type 240-262 Zinc finger, C2H2 type 240-262 C2H2-type zinc finger 254-279 Zinc-finger double domain 267-279 C2H2-type zinc finger 268-289 Zinc finger, C2H2 type 268-291 Zinc-finger of C2H2 type 268-288 C2H2-type zinc finger 592-630 Homeobox domain 904-926 C2H2-type zinc finger 904-926 C2H2-type zinc finger 918-943 Zinc-finger double domain 931-955 C2H2-type zinc finger 932-954 C2H2-type zinc finger 932-954 Zinc finger, C2H2 type 947-971 Zinc-finger double domain 960-980 C2H2-type zinc finger 960-980 Zinc finger, C2H2 type 960-987 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MADGPRCKRRKQANPRRNNVTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDD 60 61 LPTDQTVLPGRSSEREGNAKNCWEDDRKEGQEILGPEAQADEAGCTVKDDECESDAENEQ 120 121 NHDPNVEEFLQQQDTAVIFPEAPEEDQRQGTPEASGHDENGTPDAFSQLLTCPYCDRGYK 180 181 RFTSLKEHIKYRHEKNEDNFSCSLCSYTFAYRTQLERHMTSHKSGRDQRHVTQSGCNRKF 240 241 KCTECGKAFKYKHHLKEHLRIHSGEKPYECPNCKKRFSHSGSYSSHISSKKCISLIPVNG 300 301 RPRTGLKTSQCSSPSLSASPGSPTRPQIRQKIENKPLQEQLSVNQIKTEPVDYEFKPIVV 360 361 ASGINCSTPLQNGVFTGGGPLQATSSPQGMVQAVVLPTVGLVSPISINLSDIQNVLKVAV 420 421 DGNVIRQVLENNQANLASKEQETINASPIQQGGHSVISAISLPLVDQDGTTKIIINYSLE 480 481 QPSQLQVVPQNLKKENPVATNSCKSEKLPEDLTVKSEKDKSFEGGVNDSTCLLCDDCPGD 540 541 INALPELKHYDLKQPTQPPPLPAAEAEKPESSVSSATGDGNLSPSQPPLKNLLSLLKAYY 600 601 ALNAQPSAEELSKIADSVNLPLDVVKKWFEKMQAGQISVQSSEPSSPEPGKVNIPAKNND 660 661 QPQSANANEPQDSTVNLQSPLKMTNSPVLPVGSTTNGSRSSTPSPSPLNLSSSRNTQGYL 720 721 YTAEGAQEEPQVEPLDLSLPKQQGELLERSTITSVYQNSVYSVQEEPLNLSCAKKEPQKD 780 781 SCVTDSEPVVNVIPPSANPINIAIPTVTAQLPTIVAIADQNSVPCLRALAANKQTILIPQ 840 841 VAYTYSTTVSPAVQEPPLKVIQPNGNQDERQDTSSEGVSNVEDQNDSDSTPPKKKMRKTE 900 901 NGMYACDLCDKIFQKSSSLLRHKYEHTGKRPHECGICKKAFKHKHHLIEHMRLHSGEKPY 960 961 QCDKCGKRFSHSGSYSQHMNHRYSYCKREAEERDSTEQEEAGPEILSNEHVGARASP SQ 1020 1021 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1080 1081 AENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTNEA |
| Interface Residues: | 181, 182, 183, 184, 187, 191, 211, 213, 214, 217, 250, 251, 253, 254, 257, 279, 281, 282, 284, 285, 626, 627, 894, 904, 914, 915, 916, 917, 918, 920, 921, 922, 942, 943, 944, 945, 946, 947, 948, 949, 950, 970, 971, 972, 973, 974, 976, 977, 982, 985 |
| 3D-footprint Homologues: | 7w1m_H, 5k5l_F, 8ssq_A, 5kkq_D, 8ssu_A, 5yel_A, 8gn3_A, 8cuc_F, 3uk3_C, 5k5i_A, 2xsd_C, 7xrc_C, 1au7_A, 1o4x_A, 3d1n_M, 1ubd_C, 2kmk_A, 6jnm_A, 1tf3_A, 7n5w_A, 1f2i_J, 5und_A, 2jpa_A, 7ysf_A, 2drp_D, 1g2f_F, 6ml4_A, 4x9j_A, 6blw_A, 2gli_A, 6u9q_A, 5ei9_F, 1tf6_A, 5kl3_A, 2i13_A, 1mey_C, 6wmi_A, 8h9h_G, 4m9v_C, 7eyi_G, 5v3j_F, 2lt7_A, 6e94_A, 6a57_A, 7y3l_A, 2wbs_A, 1llm_D, 7txc_E, 7y3m_I, 5yj3_D |
| Binding Motifs: | MA0103.2 cCwCACCTG ZEB1_HUMAN.H10MO.B|M01611 tvCAGGTrwrs MA0103.3 ssCACCTGsss MA0103.4 CACCTG |
| Binding Sites: | MA0103.4.4 / MA0103.4.5 MA0103.4.1 / MA0103.4.12 MA0103.4.10 / MA0103.4.11 / MA0103.4.13 / MA0103.4.15 / MA0103.4.16 / MA0103.4.18 / MA0103.4.19 / MA0103.4.2 / MA0103.4.20 / MA0103.4.3 / MA0103.4.6 / MA0103.4.7 / MA0103.4.8 / MA0103.4.9 MA0103.2.1 MA0103.2.10 MA0103.2.11 MA0103.2.12 MA0103.2.13 MA0103.2.14 MA0103.2.15 MA0103.2.16 MA0103.2.17 MA0103.2.18 MA0103.2.19 MA0103.2.2 MA0103.2.20 MA0103.2.3 MA0103.2.4 / MA0103.2.5 MA0103.2.6 MA0103.2.7 MA0103.2.8 MA0103.2.9 MA0103.3.1 / MA0103.3.12 MA0103.3.10 MA0103.3.11 MA0103.3.13 MA0103.3.14 MA0103.3.15 MA0103.3.16 MA0103.3.17 MA0103.3.18 MA0103.3.19 MA0103.3.2 MA0103.3.20 MA0103.3.3 MA0103.3.4 MA0103.3.5 MA0103.3.6 MA0103.3.7 MA0103.3.8 MA0103.3.9 MA0103.4.14 MA0103.4.17 |
| Publications: | Sekido R., Murai K., Funahashi J.-i., Kamachi Y., Fujisawa-Sehara A., Nabeshima Y.-I., Kondoh H. The delta-crystallin enhancer-binding protein deltaEF1 is a repressor of E2-box-mediated gene activation. Mol. Cell. Biol. 14:5692-5700 (1994). [Pubmed] |
| Related annotations: | PaperBLAST |
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