Transcription Factor
| Accessions: | GATA2_HUMAN (HOCOMOCO 10), P23769 (JASPAR 2024) |
| Names: | Endothelial transcription factor GATA-2, GATA-binding protein 2, GATA2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P23769 |
| Length: | 480 |
| Pfam Domains: | 295-328 GATA zinc finger 349-382 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYY 60 61 ANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSP 120 121 FSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKE 180 181 VSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQP 240 241 ATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGA 300 301 TATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLW 360 361 RRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKC 420 421 MQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG 480 |
| Interface Residues: | 304, 305, 307, 317, 321, 358, 359, 361, 371, 375, 376, 379, 396, 398, 399 |
| 3D-footprint Homologues: | 3vd6_C, 4hc9_A, 3dfx_B, 1gat_A, 4gat_A |
| Binding Motifs: | MA0036.2 wrrttCTTATCWsh GATA2_HUMAN.H10MO.A|M01174 rsAGATAAgra MA0036.1 gGATr MA0036.3 tyCTTATCTby MA0036.4 CTTATCT |
| Binding Sites: | MA0036.1.1 MA0036.1.10 MA0036.1.11 MA0036.1.12 MA0036.1.13 MA0036.1.14 MA0036.1.15 MA0036.1.16 MA0036.1.17 MA0036.1.18 MA0036.1.19 MA0036.1.2 MA0036.1.20 MA0036.1.3 MA0036.1.4 MA0036.1.5 MA0036.1.6 MA0036.1.7 MA0036.1.8 MA0036.1.9 MA0036.2.1 MA0036.2.10 MA0036.2.11 MA0036.2.12 MA0036.2.13 MA0036.2.14 MA0036.2.15 MA0036.2.16 MA0036.2.17 MA0036.2.18 MA0036.2.19 MA0036.2.2 MA0036.2.20 MA0036.2.3 MA0036.2.4 MA0036.2.5 MA0036.2.6 MA0036.2.7 MA0036.2.8 MA0036.2.9 MA0036.3.1 MA0036.3.10 MA0036.3.11 MA0036.3.12 MA0036.3.13 MA0036.3.14 MA0036.3.15 MA0036.3.16 MA0036.3.17 MA0036.3.18 MA0036.3.19 MA0036.3.2 MA0036.3.20 MA0036.3.3 MA0036.3.4 MA0036.3.5 MA0036.3.6 MA0036.3.7 MA0036.3.8 MA0036.3.9 MA0036.4.4 MA0036.4.11 / MA0036.4.12 / MA0036.4.15 / MA0036.4.18 / MA0036.4.19 / MA0036.4.3 / MA0036.4.5 / MA0036.4.6 / MA0036.4.8 MA0036.4.1 / MA0036.4.2 MA0036.4.10 / MA0036.4.13 / MA0036.4.7 / MA0036.4.9 MA0036.4.14 MA0036.4.16 / MA0036.4.17 MA0036.4.20 |
| Publications: | Merika M., Orkin S. H. DNA-binding specificity of GATA family transcription factors. Mol. Cell. Biol. 13:3999-4010 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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