Transcription Factor
| Accessions: | MEF2D_DBD (HumanTF 1.0), MEF2D (HT-SELEX2 May2017) |
| Names: | MEF2D, Q05BX2_HUMAN, ENSG00000116604 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q05BX2 |
| Notes: | Ensembl ID: ENSG00000116604; DNA-binding domain sequence; TF family: MADS; Clone source: MGC, TF family: MADS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: MADS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 112 |
| Pfam Domains: | 8-57 SRF-type transcription factor (DNA-binding and dimerisation domain) |
| Sequence: (in bold interface residues) | 1 RKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDM 60 61 DKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLE |
| Interface Residues: | 1, 2, 13, 16, 17, 21, 55, 66, 91 |
| 3D-footprint Homologues: | 8q9r_F, 8q9n_B, 1c7u_A, 1n6j_A, 8q9p_B, 1egw_B, 7xuz_H, 8q9q_A, 1hbx_A, 1mnm_A, 7yq3_E |
| Binding Motifs: | MEF2D_DBD dCTAwAAATAGm MEF2D_2 CCwwATwtrG MEF2D_methyl_1 CCwwATwtrG |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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