Transcription Factor
| Accessions: | P55055 (JASPAR 2024) |
| Names: | Liver X receptor beta, NR1H2_HUMAN, Nuclear receptor NER, Nuclear receptor subfamily 1 group H member 2, Oxysterols receptor LXR-beta, Ubiquitously-expressed nuclear receptor |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P55055 |
| Length: | 460 |
| Pfam Domains: | 86-155 Zinc finger, C4 type (two domains) 256-439 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW 60 61 VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA 120 121 RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ 180 181 SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR 240 241 SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI 300 301 ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR 360 361 RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM 420 421 LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE |
| Interface Residues: | 95, 96, 98, 99, 105, 106, 108, 109, 112, 113, 139, 167, 171, 174, 188, 190 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | MA0115.1 AAAGGTCAAAGGTCAAc |
| Binding Sites: | MA0115.1.1 / MA0115.1.10 / MA0115.1.2 / MA0115.1.3 / MA0115.1.4 / MA0115.1.5 / MA0115.1.6 / MA0115.1.7 / MA0115.1.8 / MA0115.1.9 MA0115.1.11 MA0115.1.12 MA0115.1.13 MA0115.1.14 MA0115.1.15 MA0115.1.16 MA0115.1.17 MA0115.1.18 MA0115.1.19 / MA0115.1.20 |
| Publications: | Feltkamp D., Wiebel F. F., Alberti S., Gustafsson J. A. Identification of a novel DNA binding site for nuclear orphan receptor OR1. J. Biol. Chem. 274:10421-10429 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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