Transcription Factor

						

			
Accessions: 4r2q_A (3D-footprint 20231221), 4r2r_A (3D-footprint 20231221)

			
Names: Wilms tumor protein, isoform 4/CRA_a, WT1_HUMAN, WT33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P19544
Length: 88
Pfam Domains:      5-29 C2H2-type zinc finger
     5-29 Zinc finger, C2H2 type
    22-46 Zinc-finger double domain
    35-57 C2H2-type zinc finger
    35-57 Zinc finger, C2H2 type
    35-55 Zinc-finger of C2H2 type
    49-75 Zinc-finger double domain
    63-85 C2H2-type zinc finger
    63-87 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 SEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGE   60
  61 KPFSCRWPSCQKKFARSDELVRHHNMHQ
Interface Residues: 17, 18, 19, 20, 21, 23, 24, 45, 46, 47, 48, 49, 51, 52, 53, 56, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83
3D-footprint Homologues: 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 1f2i_J, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 6ml4_A, 2gli_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 8h9h_G, 5v3j_F, 6e94_A, 6wmi_A, 2lt7_A, 7y3m_I, 6a57_A, 8gn3_A, 3uk3_C, 1llm_D, 7txc_E, 5yj3_D, 5yel_A, 4m9v_C
Binding Motifs: 4r2q_A aGCCCACGC
4r2r_A AGCCCACGC
Binding Sites: 4r2q_B / 4r2r_B
4r2q_C / 4r2r_C
			
Publications: Hashimoto H, Olanrewaju Y.O, Zheng Y, Wilson G.G, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & development 28:2304-13 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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