Transcription Factor

Accessions: UP00280A (UniPROBE 20160601)
Names: Disrupter of telomere silencing protein 6, Pbf2, YER088C
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P40059
Description: Protein of unknown function, involved in telomeric gene silencing and filamentation
Length: 146
Pfam Domains: 53-96 Myb-like DNA-binding domain
54-97 Myb-like DNA-binding domain
Sequence:
(in bold interface residues)
1 QLHSLTRQPHSSSTAMSKNEAQESSPSLPASSSSSTSASASASSKNSSKNPSSWDPQDDL 60
61 LLRHLKEVKKMGWKDISQYFPNRTPNACQFRWRRLKSGNLKSNKTALIDINTYTGPLKIT 120
121 HGDETANAQQKPSKKVEENVLTEDTA
Interface Residues: 85, 86, 87, 89, 90, 93, 95
3D-footprint Homologues: 1mse_C, 2kdz_A, 3osg_A, 1ign_A, 3zqc_A
Binding Motifs: UP00280A_1 wbybkcwsCTCATCGcvycyt
Binding Sites: ACTCATCG
CCCATCGC
CCGATGAG
CCGATGCC
CCTCATCG
CGATGACC
CGATGAGA
CGATGAGC
CGCATCGC
CTCATCGA
CTCATCGC
CTCATCTC
GCGATGAC
GCGATGCC
GGCGATGA
TCATCGCA
AGCGATGC
CATCGATG
GCCATCGC
GTCATCGA
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]
Related annotations: PaperBLAST

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