Transcription Factor
| Accessions: | Sox17_DBD (HumanTF 1.0), UP00014A (UniPROBE 20160601) |
| Names: | Sox17, SOX17_MOUSE, Sox-17, SRY-box containing gene 17, Transcription factor SOX-17 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q61473 |
| Description: | SRY-box containing gene 17 |
| Notes: | Ensembl ID: ENSMUSG00000025902; DNA-binding domain sequence; TF family: HMG; Clone source: Hughes lab. |
| Length: | 101 |
| Pfam Domains: | 16-79 Domain of unknown function (DUF1898) 17-85 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 SGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTL 60 61 AEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVE |
| Interface Residues: | 19, 22, 24, 25, 28, 32, 43, 44, 45, 48, 86, 90 |
| 3D-footprint Homologues: | 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 1hry_A, 3tq6_B |
| Binding Motifs: | UP00014A_1 mwaAACAATTrAwhw Sox17_DBD_1 AACAATwdCATTGTT Sox17_DBD_2 ATGAATwwCATTCAT UP00014A_2 gwycacATTCAtryrat |
| Binding Sites: | AAAACAAT AAACAATT AACAATAA AACAATAT AACAATGG AACAATTA AACAATTC AACAATTG AATTCAAT AATTGTTA AATTGTTC ACAACAAT ACAATTGA ACAATTGT AGAACAAT AGACAATA ATAACAAT ATGAATTG ATTGTTAA TAACAATA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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