Transcription Factor
| Accessions: | NR1H4_HUMAN (HOCOMOCO 10), Q96RI1 (JASPAR 2024) |
| Names: | Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, NR1H4_HUMAN, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 486 |
| Pfam Domains: | 136-202 Zinc finger, C4 type (two domains) 291-463 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS 60 61 NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK 120 121 KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV 180 181 MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG 240 241 RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI 300 301 LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD 360 361 LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 420 421 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC 480 481 EIWDVQ |
| Interface Residues: | 145, 146, 148, 149, 155, 156, 158, 159, 162, 163, 187, 221, 223, 224, 244 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | NR1H4_HUMAN.H10MO.C|M01386 rrGGTCAatGaCCT MA1110.1 tcAATGACCyh MA1146.1 grGkTCAtTGACCyy MA1146.2 rGkTCAtTGACCy |
| Binding Sites: | MA1110.1.1 MA1110.1.10 MA1110.1.11 MA1110.1.12 MA1110.1.13 MA1110.1.14 MA1110.1.15 MA1110.1.16 MA1110.1.17 MA1110.1.18 MA1110.1.19 MA1110.1.2 MA1110.1.20 MA1110.1.3 MA1110.1.4 MA1110.1.5 MA1110.1.6 MA1110.1.7 MA1110.1.8 MA1110.1.9 |
| Publications: | Laffitte B. A., Kast H. R., Nguyen C. M., Zavacki A. M., Moore D. D., Edwards P. A. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor.. J. Biol. Chem. 275:10638-10647 (2000). [Pubmed] Hoeke MO, Heegsma J, Hoekstra M, Moshage H, Faber KN. Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. PLoS One : (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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