Transcription Factor

						

			
Accessions: 4r2s_A (3D-footprint 20231221)

			
Names: Wilms tumor protein, isoform 4/CRA_a, WT1_HUMAN, WT33
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P19544
Length: 89
Pfam Domains:      5-29 C2H2-type zinc finger
     5-29 Zinc finger, C2H2 type
    22-46 Zinc-finger double domain
    35-55 Zinc-finger of C2H2 type
    35-57 C2H2-type zinc finger
    35-57 Zinc finger, C2H2 type
    49-75 Zinc-finger double domain
    63-85 C2H2-type zinc finger
    63-87 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 SEKPYQCDFKDCERRFSRSDPLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGE   60
  61 KPFSCRWPSCQKKFARSDELVRHHNMHQR
Interface Residues: 17, 18, 19, 20, 21, 23, 24, 45, 46, 47, 48, 49, 51, 52, 53, 56, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83
3D-footprint Homologues: 7n5w_A, 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 6ml4_A, 1g2f_F, 6blw_A, 5kkq_D, 1tf6_A, 6u9q_A, 4x9j_A, 2i13_A, 5kl3_A, 2wbs_A, 1ubd_C, 7ysf_A, 5ei9_F, 2jpa_A, 8ssq_A, 1mey_C, 7w1m_H, 5und_A, 2drp_D, 1f2i_J, 7eyi_G, 5k5i_A, 2kmk_A, 8ssu_A, 2gli_A, 8h9h_G, 5v3j_F, 2lt7_A, 7y3m_I, 6e94_A, 6wmi_A, 6a57_A, 8gn3_A, 3uk3_C, 5yel_A, 1llm_D, 7txc_E, 5yj3_D, 4m9v_C
Binding Motifs: 4r2s_A annCCCACGC
Binding Sites: 4r2s_B
4r2s_C
			
Publications: Hashimoto H, Olanrewaju Y.O, Zheng Y, Wilson G.G, Zhang X, Cheng X. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. Genes & development 28:2304-13 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.