Transcription Factor
| Accessions: | Msx3_DBD (HumanTF 1.0), UP00171A (UniPROBE 20160601) |
| Names: | Msx3, MSX3_MOUSE, homeo box, Homeobox protein MSX-3, msh-like 3 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P70354 |
| Description: | homeo box, msh-like 3 |
| Notes: | Ensembl ID: ENSMUSG00000025469; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 RAPSPPPCTLRKHKTNRKPRTPFTTAQLLALERKFHQKQYLSIAERAEFSSSLSLTETQV 60 61 KIWFQNRRAKAKRLQEAELEKLKLAAKPLLPAA |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 2ld5_A, 7q3o_C, 6es3_K, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 1jgg_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1puf_B, 1k61_B, 3l1p_A |
| Binding Motifs: | UP00171A_1 mamAAcyAATTAAktw Msx3_DBD_1 syAATTAaawwsCAATTA Msx3_DBD_2 syAATTAr |
| Binding Sites: | GGTAATTA AATAATTA AATTAATT ACCAATTA ACTAATTA AGCAATTA AGTAATTA ATAATTAC ATAATTAG ATAATTGG ATTAATTA CCAATTAA CCAATTAG CTAATTAA CTAATTAG GCAATTAA GCTAATTA GTTAATTA TAATTGCA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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