Transcription Factor
| Accessions: | HOXD8_DBD (HumanTF 1.0), HOXD8 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-4E, Homeobox protein Hox-5.4, Homeobox protein Hox-D8, HOXD8, HXD8_HUMAN, ENSG00000175879 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P13378 |
| Notes: | Ensembl ID: ENSG00000175879; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 277 |
| Pfam Domains: | 197-253 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAGF 60 61 PHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPPP 120 121 PPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSSS 180 181 PSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQV 240 241 KIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQ |
| Interface Residues: | 197, 198, 199, 200, 201, 238, 239, 241, 242, 245, 246, 249, 250, 253 |
| 3D-footprint Homologues: | 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 4xrs_G, 2hos_A, 4cyc_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 7xrc_C, 2xsd_C, 1le8_A, 1e3o_C, 1o4x_A, 8g87_X, 4qtr_D, 1le8_B, 1du0_A, 6a8r_A, 4xrm_B, 1mnm_C, 1k61_B |
| Binding Motifs: | HOXD8_DBD rmwAATtarc HOXD8_3 gymATTAm HOXD8_methyl_1 rtCrTTAw HOXD8_methyl_2 gymATTAm |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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