Transcription Factor
| Accessions: | SRBP1_HUMAN (HOCOMOCO 10), P36956 (JASPAR 2024) |
| Names: | bHLHd1, Class D basic helix-loop-helix protein 1, SRBP1_HUMAN, SREBP-1, Sterol regulatory element-binding protein 1, Sterol regulatory element-binding transcription factor 1, Transcription factor SREBF1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P36956 |
| Length: | 1148 |
| Pfam Domains: | 324-374 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFDPPYAGSGAGGTD 60 61 PASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPGP 120 121 GIKEESVPLSILQTPTPQPLPGALLPQSFPAPAPPQFSSTPVLGYPSPPGGFSTGSPPGN 180 181 TQQPLPGLPLASPPGVPPVSLHTQVQSVVPQQLLTVTAAPTAAPVTTTVTSQIQQVPVLL 240 241 QPHFIKADSLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDA 300 301 EKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGTEAKLNKS 360 361 AVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKSKSLKDLVSACGSGGNTDVLMEGVKTE 420 421 VEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEPDSPVFEDSKAKPEQRPSLHSR 480 481 GMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSDTTSVYHSPGRNVLGTESRDGPGW 540 541 AQWLLPPVVWLLNGLLVLVSLVLLFVYGEPVTRPHSGPAVYFWRHRKQADLDLARGDFAQ 600 601 AAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHLLQRLWVGRWLAGRAGGLQQDCALRV 660 661 DASASARDAALVYHKLHQLHTMGKHTGGHLTATNLALSALNLAECAGDAVSVATLAEIYV 720 721 AAALRVKTSLPRALHFLTRFFLSSARQACLAQSGSVPPAMQWLCHPVGHRFFVDGDWSVL 780 781 STPWESLYSLAGNPVDPLAQVTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYL 840 841 QLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL 900 901 VEHLPRVLQESERPLPRAALHSFKAARALLGCAKAESGPASLTICEKASGYLQDSLATTP 960 961 ASSSIDKAVQLFLCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQR DLS 1020 1021 SLRRLAQSFRPAMRRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEP 1080 1081 RPTRREHAEALLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLG 1140 1141 GGTTVTSS |
| Interface Residues: | 325, 327, 328, 329, 331, 332, 335, 336, 357, 359 |
| 3D-footprint Homologues: | 2ypa_A, 1an4_A, 6g1l_A, 4h10_B, 7ssa_L, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 8osl_O, 5v0l_A, 4h10_A, 7rcu_E, 5i50_B, 1am9_A, 8osl_P, 5nj8_C |
| Binding Motifs: | MA0595.1 rTCACcCCAy SRBP1_HUMAN.H10MO.B|M01533 ggTgrssTGAk MA0829.2 rrATCACsTGATyy MA0829.3 ATCACsTGAT |
| Binding Sites: | MA0595.1.1 MA0595.1.10 MA0595.1.11 MA0595.1.12 MA0595.1.13 MA0595.1.14 MA0595.1.15 MA0595.1.16 MA0595.1.17 MA0595.1.18 MA0595.1.19 MA0595.1.2 MA0595.1.20 MA0595.1.3 MA0595.1.4 MA0595.1.5 MA0595.1.6 MA0595.1.7 MA0595.1.8 MA0595.1.9 MA0829.2.1 MA0829.2.10 MA0829.2.11 MA0829.2.12 MA0829.2.13 / MA0829.2.8 MA0829.2.14 / MA0829.2.9 MA0829.2.13 / MA0829.2.15 MA0829.2.14 / MA0829.2.16 MA0829.2.17 MA0829.2.15 / MA0829.2.18 MA0829.2.17 / MA0829.2.19 MA0829.2.2 MA0829.2.20 MA0829.2.3 MA0829.2.4 MA0829.2.1 / MA0829.2.5 MA0829.2.2 / MA0829.2.6 MA0829.2.3 / MA0829.2.7 MA0829.2.4 / MA0829.2.8 MA0829.2.9 MA0829.2.10 MA0829.2.11 MA0829.2.12 MA0829.2.16 MA0829.2.18 MA0829.2.19 MA0829.2.20 MA0829.2.5 MA0829.2.6 MA0829.2.7 MA0829.3.1 MA0829.3.10 MA0829.3.11 MA0829.3.12 MA0829.3.13 / MA0829.3.17 / MA0829.3.3 MA0829.3.14 / MA0829.3.16 / MA0829.3.2 MA0829.3.15 / MA0829.3.8 MA0829.3.18 MA0829.3.19 MA0829.3.20 MA0829.3.4 MA0829.3.5 MA0829.3.6 MA0829.3.7 MA0829.3.9 |
| Publications: | Wang X., Sato R. R., Brown M. S., Hua X., Goldstein J. L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53-62 (1994). [Pubmed] Shimano H. Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes. Prog Lipid Res 40:439-52 (2001). [Pubmed] |
| Related annotations: | PaperBLAST |
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