Transcription Factor

						

			
Accessions: 5d39_B (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 483
Pfam Domains:    16-119 STAT protein, all-alpha domain
  121-360 STAT protein, DNA binding domain
  371-449 SH2 domain
Sequence: 
(in bold interface residues)		   1 QEELKFKTGLRRLQHRVGEIHLLREALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAG   60
  61 NGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSC  120
 121 FLVEKQPPQVLKTQTKFQAGVRFLLGLRFPAKPPLVRADMVTEKQARELESTGEIINNTV  180
 181 PLENSIPGNCCSALFKNLLLKKIKRCEGTESVTEEKCAVLFSASFTLGPGKLPIQLQALS  240
 241 LPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNR  300
 301 GLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKR  360
 361 CLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIE  420
 421 NIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPATIKM  480
 481 TVE
Interface Residues: 132, 207, 247, 248, 249, 250, 251
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 5d39_BD TtcCtGgaa
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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