Transcription Factor
| Accessions: | UP00463A (UniPROBE 20160601), P33200 (JASPAR 2024) |
| Names: | AMY2, Pdr3, Pleiotropic Drug Resistance, TPE2, PDR3_YEAST, Pleiotropic drug resistance protein 3, Transcription factor PDR3 |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Pleiotropic Drug Resistance : Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome |
| Length: | 976 |
| Pfam Domains: | 13-47 Fungal Zn(2)-Cys(6) binuclear cluster domain 279-620 Fungal specific transcription factor domain |
| Sequence: (in bold interface residues) | 1 MKVKKSTRSKVSTACVNCRKRKIKCTGKYPCTNCISYDCTCVFLKKHLPQKEDSSQSLPT 60 61 TAVAPPSSHANVEASADVQHLDTAIKLDNQYYFKLMNDLIQTPVSPSATHAPDTSNNPTN 120 121 DNNILFKDDSKYQNQLVTYQNILTNLYALPPCDDTQLLIDKTKSQLNNLINSWNPEINYP 180 181 KLSSFSPRPQRSIETYLLTNKYRNKIHMTRFSFWTDQMVKSQSPDSFLATTPLVDEVFGL 240 241 FSPIQAFSLRGIGYLIKKNIENTGSSMLIDTKETIYLILRLFDLCYEHLIQGCISISNPL 300 301 ENYLQKIKQTPTTTASASLPTSPAPLSNDLVISVIHQLPQPFIQSITGFTTTQLIENLHD 360 361 SFSMFRIVTQMYAQHRKRFAEFLNQAFSLPHQEKSVLFSSFCSSEYLLSTLCYAYYNVTL 420 421 YHMLDINTLDYLEILVSLLEIQNEIDERFGFEKMLEVAVTCSTKMGLSRWEYYVGIDENT 480 481 AERRRKIWWKIYSLEKRFLTDLGDLSLINEHQMNCLLPKDFRDMGFINHKEFLTKIGTSS 540 541 LSPSSPKLKNLSLSRLIEYGELAIAQIVGDFFSETLYNEKFTSLEVSVKPTIIRQKLLEK 600 601 VFEDIESFRLKLAKIKLHTSRVFQVAHCKYPEYPKNDLIEAAKFVSYHKNTWFSILGAVN 660 661 NLIARLSEDPEVITEQSMKYANEMFQEWREINQFLIQVDTDFIVWACLDFYELIFFVMAS 720 721 KFYVEDPHITLEDVINTLKVFKRITNIISFFNNNLDEKDYDCQTFREFSRSSSLVAISIR 780 781 IIFLKYCYAEQIDRAEFIERLKEVEPGLSDLLREFFDTRSFIYRYMLKSVEKSGFHLIIR 840 841 KMLESDYKFLYRDKLATGNIPDQGNSSQISQLYDSTAPSYNNASASAANSPLKLSSLLNS 900 901 GEESYTQDASENVPCNLRHQDRSLQQTKRQHSAPSQISANENNIYNLGTLEEFVSSGDLT 960 961 DLYHTLWNDNTSYPFL |
| Interface Residues: | 8, 10, 12, 21, 22, 23, 38, 110, 117, 604, 605 |
| 3D-footprint Homologues: | 7uy7_A, 6o19_A, 2er8_C, 1hwt_C, 1pyi_A, 7uik_T, 1zme_D, 6gys_C, 3coq_A, 5hr4_C, 6fl1_A |
| Binding Motifs: | MA0353.1 TCCGCGGA UP00463A_1 rcsbckwTCCGCGGAAmrggrs |
| Binding Sites: | CCGCGGGA AACGGAAC ACCCGCGG ACGGAACC ATCCGCGG CCCCGCGG CCCGCGGG CCGCGGAA CGGATCCG TCCCGGGA TCCGCGGA TTCCGGAA ACCGCGGA CCCGCGGA CCCGCGGC CCGCGGAC CCGCGGAG CCGCGGCA CGCGGAAC GCCGCGGA |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] MacIsaac K.D, Wang T, Gordon D.B, Gifford D.K, Stormo G.D, Fraenkel E. An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC bioinformatics 7:113 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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