Transcription Factor
| Accessions: | Hoxc10_DBD (HumanTF 1.0), UP00245A (UniPROBE 20160601) |
| Names: | Homeobox protein Hox-3.6, Homeobox protein Hox-C10, Hoxc10, HXC10_MOUSE, AI506621, homeo box C10, Hox-3.6, Hoxc-10 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P31257 |
| Description: | homeo box C10 |
| Notes: | Ensembl ID: ENSMUSG00000022484; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 IKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQV 60 61 KIWFQNRRMKLKKMNRENRIRELTSNFNFT |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 5zfz_A, 1fjl_B, 3d1n_M, 1ig7_A, 6a8r_A, 2h1k_B, 6m3d_C, 1puf_A, 3cmy_A, 1nk2_P, 1zq3_P, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 7psx_B, 3rkq_B, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 5hod_A, 3a01_E, 1jgg_B, 5jlw_D, 3lnq_A, 4xrs_G, 2hdd_A, 1le8_A, 1au7_A, 2xsd_C, 7xrc_C, 1e3o_C, 6fqp_B, 6fqq_E, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X |
| Binding Motifs: | UP00245A_1 twarGTCRTAAAaysk Hoxc10_DBD_1 gTCrTWAAAw Hoxc10_DBD_2 gyaATAAAAa |
| Binding Sites: | TAATAAAA GGTAATTA ATAATTAC ATCGTAAA ATTTTATG CAATAAAA CCATAAAA CCCATAAA CTCGTAAA GCAATAAA GGTCGTAA GGTCGTTA GTAATAAA GTAATTAC GTCATAAA GTCATTAA GTCGTTAA GTTTACGA TCATAAAA TCGTAAAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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