Transcription Factor
| Accessions: | UP00309A (UniPROBE 20160601), UP00397A (UniPROBE 20160601) |
| Names: | Cbf1, CBP-1, Centromere promoter factor 1, Centromere-binding factor 1, Centromere-binding protein 1, CEP1, CP1, CPF1, J1730, YJR060W |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P17106 |
| Description: | Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA |
| Length: | 351 |
| Pfam Domains: | 223-270 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNSLANNNKLSTEDEEIHSARKRGYNEEQNYSEARKKQRDQGLLSQESNDGNIDSALLSE 60 61 GATLKGTQSQYESGLTSNKDEKGSDDEDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQ 120 121 TNANGEHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDTLIPLAEHDRGPE 180 181 HQQDDEDNDDADIDLKKDISMQPGRRGRKPTTLATTDEWKKQRKDSHKEVERRRRENINT 240 241 AINVLSDLLPVRESSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANE 300 301 KLQEELGNAYKEIEYMKRVLRKEGIEYEDMHTHKKQENERKSTRSDNPHEA |
| Interface Residues: | 224, 226, 227, 228, 230, 231, 234, 235, 256, 286, 289 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 4h10_B, 7ssa_L, 5gnj_I, 6g1l_A, 4zpk_A, 7xi3_A, 5nj8_D, 7d8t_A, 5eyo_A, 5v0l_A, 4h10_A, 7f2f_B, 1am9_A, 8osl_P, 2ypa_A, 8osl_O, 5v0l_B, 5gke_A |
| Binding Motifs: | UP00309A_1 kaycwgkCACGTGactbvymg UP00397A_1 wswaywsrTCACGTGmtcdgmy |
| Binding Sites: | AACACGTG ACACGTGA ACACGTGC ACACGTGG ACACGTGT ACCACGTG AGCACGTG ATCACGTG CACGTGAC CACGTGAG CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGGC CACGTGTA CACGTGTC CCACGTGA CCACGTGC CCACGTGG GCACGTGA GCACGTGC TCACGTGA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Berger M.F, Philippakis A.A, Qureshi A.M, He F.S, Estep P.W, Bulyk M.L. Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nature biotechnology 24:1429-35 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.