Transcription Factor

						

			
Accessions: NEUROG2_full (HumanTF 1.0)

			
Names: bHLHa8, Class A basic helix-loop-helix protein 8, NEUROG2, Neurogenin-2, NGN-2, NGN2_HUMAN, Protein atonal homolog 4
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q9H2A3
Notes: Ensembl ID: ENSG00000178403; Full protein sequence; TF family: bHLH; Clone source: hORFeome
Length: 273
Pfam Domains:   113-164 Helix-loop-helix DNA-binding domain
Sequence: 
(in bold interface residues)		   1 MFVKSETLELKEEEDVLVLLGSASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAG   60
  61 QGARGGVAAGAEGCRPARLLGLVHDCKRRPSRARAVSRGAKTAETVQRIKKTRRLKANNR  120
 121 ERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNYIWALTETLRLADHCGGGGGG  180
 181 LPGALFSEAVLLSPGGASAALSSSGDSPSPASTWSCTNSPAPSSSVSSNSTSPYSCTLSP  240
 241 ASPAGSDMDYWQPPPPDKHRYAPHLPIARDCI*
Interface Residues: 114, 117, 118, 120, 121, 122, 124, 125, 150
3D-footprint Homologues: 7z5k_B, 2ypa_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D, 7ssa_L
Binding Motifs: NEUROG2_full raCATATGtY
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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