Transcription Factor
| Accessions: | Q9Y2L8 (JASPAR 2024) |
| Names: | Zfp-95, Zinc finger protein 95 homolog, Zinc finger protein with KRAB and SCAN domains 5, ZKSC5_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9Y2L8 |
| Length: | 839 |
| Pfam Domains: | 45-138 SCAN domain 222-258 KRAB box 346-368 Zinc finger, C2H2 type 346-366 C2H2-type zinc finger 363-384 Zinc-finger double domain 374-396 C2H2-type zinc finger 374-396 C2H2-type zinc finger 374-396 Zinc finger, C2H2 type 388-411 Zinc-finger double domain 401-412 C2H2-type zinc finger 402-424 C2H2-type zinc finger 402-424 Zinc finger, C2H2 type 416-440 Zinc-finger double domain 430-452 Zinc finger, C2H2 type 430-452 C2H2-type zinc finger 432-452 C2H2-type zinc finger 539-558 Zinc-finger double domain 548-560 C2H2-type zinc finger 549-571 C2H2-type zinc finger 549-571 Zinc finger, C2H2 type 564-587 Zinc-finger double domain 577-599 C2H2-type zinc finger 577-599 Zinc finger, C2H2 type 577-599 C2H2-type zinc finger 591-614 Zinc-finger double domain 604-627 C2H2-type zinc finger 605-627 C2H2-type zinc finger 605-627 Zinc finger, C2H2 type 619-643 Zinc-finger double domain 633-655 C2H2-type zinc finger 633-655 Zinc finger, C2H2 type 633-656 C2H2-type zinc finger 651-670 Zinc-finger double domain 661-680 C2H2-type zinc finger 712-728 Zinc-finger double domain 717-739 C2H2-type zinc finger 717-739 C2H2-type zinc finger 717-739 Zinc finger, C2H2 type 732-751 Zinc-finger double domain 773-795 C2H2-type zinc finger 773-795 Zinc finger, C2H2 type 787-811 Zinc-finger double domain 801-823 C2H2-type zinc finger 801-823 C2H2-type zinc finger 801-823 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MIMTESREVIDLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNPPTFETFYQRFRHFQYHE 60 61 ASGPREALSQLRVLCCEWLRPELHTKEQILELLVLEQFLTILPEEFQPWVREHHPESGEE 120 121 AVAVIENIQRELEERRQQIVACPDVLPRKMATPGAVQESCSPHPLTVDTQPEQAPQKPRL 180 181 LEENALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQK 240 241 SLYRDDRKENYGSITSMGYESRDNMELIVKQISDDSESHWVAPEHTERSVPQDPDFAEVS 300 301 DLKGMVQRWQVNPTVGKSRQNPSQKRDLDAITDISPKQSTHGERGHRCSDCGKFFLQASN 360 361 FIQHRRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQH 420 421 HSVHSGERPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKISEYS 480 481 EADMELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHK 540 541 KSSTGERPHKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHT 600 601 GEKPYTCPLCGKAFRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKS 660 661 HQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCD 720 721 ICGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGR 780 781 GFTLKSHLNQHQRIHTGEKPFQCKECGMNFSWSCSLFKHLRSHERTDPINTLSVEGSLL |
| Interface Residues: | 356, 357, 358, 359, 360, 363, 384, 385, 386, 387, 388, 390, 391, 412, 413, 414, 415, 416, 419, 441, 442, 443, 444, 447, 488, 490, 491, 494, 559, 560, 562, 563, 565, 566, 568, 569, 570, 572, 587, 588, 589, 590, 591, 593, 594, 595, 598, 615, 616, 617, 618, 619, 620, 621, 622, 623, 626, 643, 644, 645, 646, 647, 649, 650, 651, 672, 673, 674, 675, 678, 682, 698, 699, 700, 701, 704, 707, 728, 730, 731, 734, 740, 754, 756, 758, 759, 762, 766, 783, 784, 785, 786, 787, 812, 814, 818 |
| 3D-footprint Homologues: | 7n5w_A, 6u9q_A, 2kmk_A, 8h9h_G, 7eyi_G, 6e94_A, 3uk3_C, 1llm_D, 2lt7_A, 5v3j_F, 2wbs_A, 1tf3_A, 7w1m_H, 6jnm_A, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 5kkq_D, 1ubd_C, 5ei9_F, 1mey_C, 5kl3_A, 1f2i_J, 6wmi_A, 8ssq_A, 5und_A, 1g2f_F, 2i13_A, 7y3m_I, 6a57_A, 2jpa_A, 7y3l_A, 8cuc_F, 6blw_A, 5yel_A, 2drp_D, 5k5i_A, 2gli_A, 4m9v_C, 8gn3_A, 7txc_E, 5k5l_F, 5yj3_D, 7ysf_A |
| Binding Motifs: | MA1652.1 rgaGGArGTGAgrr MA1652.2 GGArGTGAg |
| Binding Sites: | MA1652.1.1 MA1652.1.10 MA1652.1.11 MA1652.1.12 MA1652.1.13 / MA1652.1.8 MA1652.1.14 MA1652.1.15 / MA1652.1.5 / MA1652.1.6 / MA1652.1.9 MA1652.1.10 / MA1652.1.16 MA1652.1.17 MA1652.1.11 / MA1652.1.18 MA1652.1.12 / MA1652.1.19 MA1652.1.1 / MA1652.1.2 MA1652.1.13 / MA1652.1.20 MA1652.1.2 / MA1652.1.3 MA1652.1.3 / MA1652.1.4 MA1652.1.4 / MA1652.1.5 MA1652.1.6 / MA1652.1.7 MA1652.1.7 / MA1652.1.8 MA1652.1.9 MA1652.1.14 MA1652.1.15 MA1652.1.16 MA1652.1.17 MA1652.1.18 MA1652.1.19 MA1652.1.20 MA1652.2.1 / MA1652.2.11 / MA1652.2.17 / MA1652.2.19 / MA1652.2.4 MA1652.2.10 / MA1652.2.13 MA1652.2.12 / MA1652.2.20 / MA1652.2.8 MA1652.2.14 MA1652.2.15 MA1652.2.16 MA1652.2.18 MA1652.2.2 MA1652.2.3 MA1652.2.5 / MA1652.2.9 MA1652.2.6 MA1652.2.7 |
| Publications: | Weirauch MT, Cote A, Norel R, Annala M, Zhao Y, Riley TR, Saez-Rodriguez J, Cokelaer T, Vedenko A, Talukder S; DREAM5 Consortium, Bussemaker HJ, Morris QD, Bulyk ML, Stolovitzky G, Hughes TR. Evaluation of methods for modeling transcription factor sequence specificity. Nat Biotechnol 31:126-34 (2013). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.