Transcription Factor
| Accessions: | 5uhb_F (3D-footprint 20231221) |
| Names: | RNA polymerase sigma factor SigA, SIGA_MYCTU, Sigma-A |
| Organisms: | Mycobacterium tuberculosis, strain ATCC 25618 / H37Rv |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P9WGI1 |
| Length: | 320 |
| Pfam Domains: | 19-53 Sigma-70 factor, region 1.2 89-159 Sigma-70 region 2 168-242 Sigma-70 region 3 255-308 Sigma-70, region 4 |
| Sequence: (in bold interface residues) | 1 DESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTEL 60 61 SERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNL 120 121 GLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQREL 180 181 LQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIEGDSQLGDFIEDSEAVVAV 240 241 DAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIES 300 301 KTMSKLRHPSRSQVLRDYLD |
| Interface Residues: | 281, 282, 291, 292, 293, 294, 296, 297 |
| 3D-footprint Homologues: | 3n97_A, 6ido_B, 8cyf_B |
| Binding Motifs: | 5uhb_F TAnaATGG |
| Binding Sites: | 5uhb_G 5uhb_H |
| Publications: | Lin W, Mandal S, Degen D, Liu Y, Ebright YW, Li S, Feng Y, Zhang Y, Mandal S, Jiang Y, Liu S, Gigliotti M, Talaue M, Connell N, Das K, Arnold E, Ebright RH. Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol Cell 66:169-179 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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