Transcription Factor

						

			
Accessions: A6NNA5 (JASPAR 2024)

			
Names: Dorsal root ganglia homeobox protein, DRGX_HUMAN, Paired-related homeobox protein-like 1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: A6NNA5
Length: 263
Pfam Domains:     34-90 Homeobox domain
  201-219 OAR domain
Sequence: 
(in bold interface residues)		   1 MFYFHCPPQLEGTATFGNHSSGDFDDGFLRRKQRRNRTTFTLQQLEALEAVFAQTHYPDV   60
  61 FTREELAMKINLTEARVQVWFQNRRAKWRKTERGASDQEPGAKEPMAEVTPPPVRNINSP  120
 121 PPGDQARSKKEALEAQQSLGRTVGPAGPFFPSCLPGTLLNTATYAQALSHVASLKGGPLC  180
 181 SCCVPDPMGLSFLPTYGCQSNRTASVATLRMKAREHSEAVLQSANLLPSTSSSPGPVAKP  240
 241 APPDGSQEKTSPTKEQSEAEKSV
Interface Residues: 33, 34, 35, 36, 37, 75, 76, 78, 79, 82, 83, 86, 87, 90
3D-footprint Homologues: 4j19_B, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 5zjt_E, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1le8_A, 7xrc_C, 2xsd_C, 1e3o_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D
Binding Motifs: MA1481.1 yyAATTAs
MA1481.2 yAATTA
			
Publications: Monteiro CB, Costa MF, Reguenga C, Lima D, Castro DS, Monteiro FA. Paired related homeobox protein-like 1 (Prrxl1) controls its own expression by a transcriptional autorepression mechanism. FEBS Lett 588:3475-82 (2014). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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