Transcription Factor

Accessions: T098480_1.02 (CISBP 1.02), Q04787 (JASPAR 2024)
Names: bsh, T098480_1.02;, BSH_DROME
Organisms: Drosophila melanogaster
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q04787
Notes: experiment type:PBM, family:Homeodomain
Length: 429
Pfam Domains: 275-331 Homeobox domain
Sequence:
(in bold interface residues)
1 MAMLNEASLSPADAHAHANATTPTHSKAAAMASATTMLTTKTPFSIEHILFQNLNSASNN 60
61 NNSSDTNGIAANTNNYAPKSSRNAVKSARSAFAHDNNPHKHPSQHSHPPQSHPPASASAS 120
121 ATATARSNQAASGYAGEDYGKSMHSTPRSNHHSRHGTSHYNGDQISQQLGSGAAQHPPVP 180
181 TTQPQPPPPPPLNGGSGASNGVLYPNAPYTDHGFLQMTLGYLSPSSGTYKSVDPYFLSQA 240
241 SLFGGAPFFGAPGCVPELALGLGMGVNALRHCRRRKARTVFSDPQLSGLEKRFEGQRYLS 300
301 TPERVELATALGLSETQVKTWFQNRRMKHKKQLRRRDNANEPVDFSRSEPGKQPGEATSS 360
361 SGDSKHGKLNPGSVGGTPTQPTSEQQLQMCLMQQGYSTDDYSDLEADSGDEDNSSDVDIV 420
421 GDAKLYQLT
Interface Residues: 274, 275, 276, 277, 278, 316, 317, 319, 320, 323, 324, 327, 328, 331
3D-footprint Homologues: 4j19_B, 1fjl_B, 6a8r_A, 3d1n_M, 1ig7_A, 1puf_A, 5zfz_A, 2h1k_B, 3cmy_A, 1nk2_P, 1zq3_P, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1b72_A, 2hos_A, 5jlw_D, 4cyc_A, 2d5v_B, 4xrs_G, 3a01_E, 5flv_I, 5zjt_E, 1au7_A, 2hdd_A, 1le8_A, 2xsd_C, 7xrc_C, 1e3o_C, 4xrm_B, 1o4x_A, 1le8_B, 1du0_A, 3l1p_A, 1mnm_C, 1puf_B, 8g87_X, 1k61_B, 4qtr_D
Binding Motifs: MA0214.1 tTAATkr
M1089_1.02 swTAAtkrsy
Binding Sites: MA0214.1.8
MA0214.1.20 / MA0214.1.4
MA0214.1.16 / MA0214.1.17
MA0214.1.18
MA0214.1.1
MA0214.1.10 / MA0214.1.2
MA0214.1.11
MA0214.1.12 / MA0214.1.14
MA0214.1.13
MA0214.1.15
MA0214.1.19
MA0214.1.3
MA0214.1.5
MA0214.1.6
MA0214.1.7
MA0214.1.9
Publications: Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed]
Related annotations: PaperBLAST

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