Transcription Factor
| Accessions: | Q9WV30 (JASPAR 2024) |
| Names: | NF-AT5, NFAT5_MOUSE, Nuclear factor of activated T-cells 5, Rel domain-containing transcription factor NFAT5, T-cell transcription factor NFAT5 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9WV30 |
| Length: | 1534 |
| Pfam Domains: | 282-437 Rel homology domain (RHD) |
| Sequence: (in bold interface residues) | 1 MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPPRETSVASMSQTSGGEAGSPP 60 61 PAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVS 120 121 EKQLTGNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSP 180 181 SNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQL 240 241 TTDNKGNSKAGNGTLDSQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEG 300 301 SRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEV 360 361 DIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIT 420 421 RKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQE 480 481 NVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFT 540 541 YTPDPAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNVDKVTILPNALITPLISSSM 600 601 IKTEDVTPMEVTSEKRSSPIFQTTKSIGSTQQTLETISNIAGGAPFSSPSSSSHLTPESE 660 661 NQQQLQPKAYNPETLTTIQTQDISQPGTFPAVSAASQLPSSDALLQQATQFQTREAQSRD 720 721 TIQSDTVVNLSQLTEASQQQQSPLQEQAQTLQQQIPSNIFPSPSSVSQLQSTIQQLQAGS 780 781 FTGSAAGGRSGSVDLVQQVLEAQQQLSSVLFSTPDGNENVQEQLNADIFQVSQIQNSVSP 840 841 GMFSSAESAVHTRPDNLLPGRADSVHQQTENTLSNQQQQQQQQQQVMESSAAMVMEMQQS 900 901 ICQAAAQIQSELFPSAASASGSLQQSPVYQQPSHMMSALPTNEDMQMQCELFSSPPAASG 960 961 NETSTTTTPQVATPGSTMFQTPSSGDGEETGAQAKQIQNSVFQTMVQMQRSGDSQPQVNL 1020 1021 FSSTKNIMSVQNNGTQQQGNSLFQQGSEMMSLQSGNFLQQSSHSQAQLFHPQNPIADAQN 1080 1081 LSQETQGSIFHSPNPIVHSQTSTASSEQLQPSMFHSQNTIAVLQGSSVPQDQQSPNIFLS 1140 1141 QSSINNLQTNTVAQEEQISFFAAQNSISPLQSTSNTEQQAAFQQQPPISHIQTPILSQEQ 1200 1201 AQPSQQGLFQPQVALGSLPPNPMPQNQQGPIFQTQRPIVGMQSNSPSQEQQQQQQQQQQQ 1260 1261 QQQQQQQQQSILFSNQNAMATMASQKQPPPNMMFSPNQNPMASQEQQNQSIFHQQSNMAP 1320 1321 MNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTSLFHSSPQIQLVQGSPSSQDQQVTLFLS 1380 1381 PASMSALQTSINQPDMQQSPLYSPQNNIPGIQGSTSSPQPQATLFHNTTGGTINQIQNSP 1440 1441 GSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAINQQGQPQNEGQSSVTTLLSQQMPE 1500 1501 TSPLASSVNSSQNMEKIDLLVSLQSQGNNLTGSF |
| Interface Residues: | 293, 295, 296, 298, 299, 302, 389, 406, 440, 442, 469, 501, 530, 531 |
| 3D-footprint Homologues: | 1imh_C, 2ram_A, 7cli_B, 1a3q_A, 1p7h_L, 1a66_A, 2o61_A, 1nfk_A |
| Binding Motifs: | MA0606.2 amATGGAAAAtk MA0606.3 ATGGAAAA |
| Binding Sites: | MA0606.3.5 MA0606.3.1 MA0606.3.12 MA0606.2.1 MA0606.2.10 / MA0606.2.9 MA0606.2.11 MA0606.2.12 MA0606.2.13 MA0606.2.14 MA0606.2.15 / MA0606.2.16 MA0606.2.16 / MA0606.2.17 MA0606.2.17 / MA0606.2.18 MA0606.2.18 / MA0606.2.19 MA0606.2.19 / MA0606.2.20 MA0606.2.1 / MA0606.2.2 MA0606.2.20 MA0606.2.2 / MA0606.2.3 MA0606.2.4 MA0606.2.5 MA0606.2.6 MA0606.2.7 MA0606.2.8 MA0606.2.8 / MA0606.2.9 MA0606.2.10 MA0606.2.15 MA0606.2.3 MA0606.3.10 / MA0606.3.6 MA0606.3.11 / MA0606.3.14 / MA0606.3.7 MA0606.3.13 / MA0606.3.16 / MA0606.3.17 MA0606.3.15 MA0606.3.18 MA0606.3.19 / MA0606.3.2 / MA0606.3.4 / MA0606.3.9 MA0606.3.20 MA0606.3.3 MA0606.3.8 |
| Publications: | Badran B. M., Wolinsky S. M., Burny A., Willard-Gallo K. E. Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50.. J. Biol. Chem. 277:47136-48 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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