Transcription Factor
| Accessions: | Q6IV72 (JASPAR 2024) |
| Names: | ZN425_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q6IV72 |
| Length: | 752 |
| Pfam Domains: | 9-49 KRAB box 190-212 C2H2-type zinc finger 190-214 C2H2-type zinc finger 246-268 C2H2-type zinc finger 260-284 Zinc-finger double domain 274-296 Zinc finger, C2H2 type 274-290 C2H2-type zinc finger 274-294 C2H2-type zinc finger 288-312 Zinc-finger double domain 302-324 Zinc finger, C2H2 type 302-325 C2H2-type zinc finger 302-324 C2H2-type zinc finger 317-339 Zinc-finger double domain 330-352 C2H2-type zinc finger 345-369 Zinc-finger double domain 358-380 C2H2-type zinc finger 358-380 Zinc finger, C2H2 type 358-381 C2H2-type zinc finger 372-395 Zinc-finger double domain 401-423 Zinc-finger double domain 414-430 C2H2-type zinc finger 414-434 C2H2-type zinc finger 414-434 Zinc finger, C2H2 type 433-451 Zinc-finger double domain 442-464 C2H2-type zinc finger 457-481 Zinc-finger double domain 470-492 Zinc finger, C2H2 type 470-480 C2H2-type zinc finger 485-508 Zinc-finger double domain 498-520 Zinc finger, C2H2 type 498-520 C2H2-type zinc finger 498-520 C2H2-type zinc finger 513-536 Zinc-finger double domain 526-548 Zinc finger, C2H2 type 526-549 C2H2-type zinc finger 540-564 Zinc-finger double domain 554-576 Zinc finger, C2H2 type 554-564 C2H2-type zinc finger 554-576 C2H2-type zinc finger 570-593 Zinc-finger double domain 582-604 Zinc finger, C2H2 type 582-605 C2H2-type zinc finger 582-604 C2H2-type zinc finger 597-619 Zinc-finger double domain 610-632 Zinc finger, C2H2 type 610-620 C2H2-type zinc finger 610-632 C2H2-type zinc finger 624-649 Zinc-finger double domain 638-660 C2H2-type zinc finger 638-660 Zinc finger, C2H2 type 653-675 Zinc-finger double domain 666-688 C2H2-type zinc finger 666-688 Zinc finger, C2H2 type 680-704 Zinc-finger double domain 694-716 Zinc finger, C2H2 type 694-716 C2H2-type zinc finger 694-711 C2H2-type zinc finger 708-733 Zinc-finger double domain 722-740 C2H2-type zinc finger 722-744 Zinc finger, C2H2 type 722-744 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAEPASVTVTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLGYAFSKPDLITW 60 61 MEQGRMLLISEQGCLDKTRRTTSPPTDEQLNMKNTGKLLCFDDEGTPRTKEEDCRLNGPQ 120 121 KQDLCAALRGKERKILLAQTATFQSPSLRETEILNKKVSITAYDPDKKDLRHKPRETPGR 180 181 LEIPTGPRCYSCYVCRKVFQVRRDLLKHKRSHSKSQLCRYPKYKNSSRGKSELRRTQRLL 240 241 CQKKRFQCSECEKSYFLKGSLVTHQVVHTGQRPYPCPECDKTFRYRANLKKHLCLHRGER 300 301 PFCCGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKVHLTQHSGKRPFHC 360 361 PECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYKIKLDEHIRVHTGEKPFSCPECN 420 421 KSFRLKRSLKAHGLQHIGKRPFQCPECSRGFFWRNAMRAHQRLHSEQKPFPCAECGKRFT 480 481 RPSKLACHTRVHDRQKEFPCGECKKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRRRAH 540 541 LTEHTRLHSGEEPFQCPECDKSFSWKASMKFHQRMHRDEKPFACGECDKTYTHQSQLTEH 600 601 LRLHSGEKPYQCPECEKTFRLKGNLKSHLLQHSGQKPFSCVMCGKSFTQQYRLTEHIRVH 660 661 SGEKPFQCPECDKSYCIRGSLKVHLYKHSGERPFQCPECGKGFLQKRSLKAHLCLHSGER 720 721 PFSCDECGRSFTYVGALKTHIAVHAKEKPSSL |
| Interface Residues: | 246, 257, 258, 259, 260, 263, 266, 284, 285, 287, 288, 291, 313, 314, 315, 316, 319, 341, 343, 344, 347, 351, 368, 369, 371, 372, 375, 396, 397, 398, 399, 400, 401, 402, 403, 424, 425, 426, 427, 428, 430, 431, 434, 453, 454, 455, 456, 459, 480, 481, 482, 483, 484, 486, 487, 489, 490, 493, 508, 509, 511, 512, 515, 537, 538, 539, 540, 543, 546, 564, 565, 566, 567, 568, 569, 571, 574, 575, 577, 591, 592, 593, 594, 595, 596, 598, 599, 600, 603, 620, 621, 622, 623, 624, 625, 627, 628, 648, 649, 650, 651, 652, 655, 676, 677, 679, 680, 682, 683, 704, 705, 706, 707, 708, 710, 711, 733, 734, 735, 736, 739, 743 |
| 3D-footprint Homologues: | 2kmk_A, 8ssq_A, 1tf6_A, 5k5l_F, 1ubd_C, 8cuc_F, 7y3l_A, 6jnm_A, 1llm_D, 7w1m_H, 8ssu_A, 5yj3_D, 5ei9_F, 5kl3_A, 6e94_A, 6a57_A, 2gli_A, 2drp_D, 5yel_A, 2jpa_A, 1tf3_A, 5v3j_F, 1f2i_J, 2wbs_A, 5kkq_D, 7n5w_A, 6blw_A, 4x9j_A, 8h9h_G, 4m9v_C, 2lt7_A, 7txc_E, 6ml4_A, 6u9q_A, 7ysf_A, 3uk3_C, 5k5i_A, 1g2f_F, 8gn3_A, 7y3m_I |
| Binding Motifs: | UN0323.1 ssgAGGGCCyy UN0323.2 gAGGGCC |
| Binding Sites: | UN0323.1.1 / UN0323.1.2 UN0323.1.10 UN0323.1.11 / UN0323.1.7 UN0323.1.10 / UN0323.1.12 UN0323.1.11 / UN0323.1.13 UN0323.1.12 / UN0323.1.14 UN0323.1.13 / UN0323.1.15 UN0323.1.14 / UN0323.1.16 UN0323.1.15 / UN0323.1.17 UN0323.1.16 / UN0323.1.18 UN0323.1.18 / UN0323.1.19 UN0323.1.2 / UN0323.1.3 UN0323.1.19 / UN0323.1.20 UN0323.1.3 UN0323.1.4 UN0323.1.4 / UN0323.1.5 UN0323.1.5 / UN0323.1.6 UN0323.1.7 UN0323.1.6 / UN0323.1.8 UN0323.1.9 UN0323.1.1 UN0323.1.17 UN0323.1.20 UN0323.1.8 UN0323.1.9 UN0323.2.1 / UN0323.2.8 UN0323.2.10 / UN0323.2.13 / UN0323.2.18 / UN0323.2.9 UN0323.2.11 UN0323.2.12 / UN0323.2.15 / UN0323.2.16 / UN0323.2.19 / UN0323.2.2 / UN0323.2.4 / UN0323.2.7 UN0323.2.14 UN0323.2.17 UN0323.2.20 UN0323.2.3 UN0323.2.5 UN0323.2.6 |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.