Transcription Factor

						

			
Accessions: 1c0w_B (3D-footprint 20231221)

			
Names: DIPHTHERIA TOXIN REPRESSOR, DTXR_CORDI, Iron-dependent diphtheria tox regulatory element, Tox regulatory factor
Organisms: Corynebacterium diphtheriae, strain ATCC 700971 / NCTC 13129 / Biotype gravis
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0DJL7
Length: 219
Pfam Domains:      2-61 Iron dependent repressor, N-terminal DNA binding domain
   64-133 Iron dependent repressor, metal binding and dimerisation domain
  155-217 FeoA domain
Sequence: 
(in bold interface residues)		   1 KDLVDTTEMYLRTIYELEEEGVTPLRARIAERLEQSGPTVSQTVARMERDGLVVVASDRS   60
  61 LQMTPTGRTLATAVMRKHRLAERLLTDIIGLDINKVHDEACRWEHVMSDEVERRLVKVLK  120
 121 DVSRSPFGNPIPGLDELGVAPGTRVIDAATSMPRKVRIVQINEIFQVETDQFTQLLDADI  180
 181 RVGSEVEIVDRDGHITLSHNGKDVELLDDLAHTIRIEEL
Interface Residues: 36, 38, 39, 41, 42, 46
3D-footprint Homologues: 1f5t_A, 7b24_C, 1u8r_B, 2isz_B, 1ddn_B, 4lln_I
Binding Motifs: 1c0w_ABCD TnAGGTAGCCTACCT
1c0w_B ttAGG
Binding Sites: 1c0w_E
1c0w_F
			
Publications: Pohl E, Holmes R.K, Hol W.G. Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain. Journal of molecular biology 292:653-67 (1999). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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