Transcription Factor
| Accessions: | 2f8x_C (3D-footprint 20231221), 3v79_C (3D-footprint 20231221) |
| Names: | CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Recombining binding protein suppressor of hairless, isoform 4, Renal carcinoma antigen NY-REN-30, SUH_HUMAN, Recombining binding protein suppressor of hairless |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q06330 |
| Length: | 424 |
| Pfam Domains: | 23-154 LAG1, DNA binding 155-304 Beta-trefoil DNA-binding domain 332-420 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKK 60 61 EQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVK 120 121 MFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLH 180 181 VEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLII 240 241 RKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND 300 301 GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRV 360 361 WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTY 420 421 TPEP |
| Interface Residues: | 36, 39, 41, 141, 142, 145, 170, 171, 172 |
| 3D-footprint Homologues: | 3brd_A, 3iag_C, 5e24_E |
| Binding Motifs: | 2f8x_C TTCCCACA 3v79_C TGTGGGAA |
| Binding Sites: | 2f8x_X / 3v79_X 2f8x_Y / 3v79_Y |
| Publications: | Nam Y, Sliz P, Song L, Aster J.C, Blacklow S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124:973-83 (2006). [Pubmed] Choi S.H, Wales T.E, Nam Y, O'Donovan D.J, Sliz P, Engen J.R, Blacklow S.C. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993) 20:340-9 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.