Transcription Factor
| Accessions: | 2f8x_C (3D-footprint 20231221), 3v79_C (3D-footprint 20231221) |
| Names: | CBF-1, J kappa-recombination signal-binding protein, RBP-J kappa, RBP-JK, Recombining binding protein suppressor of hairless, isoform 4, Renal carcinoma antigen NY-REN-30, SUH_HUMAN, Recombining binding protein suppressor of hairless |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q06330 |
| Length: | 424 |
| Pfam Domains: | 23-154 LAG1, DNA binding 155-304 Beta-trefoil DNA-binding domain 332-420 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKK 60 61 EQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVK 120 121 MFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLH 180 181 VEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLII 240 241 RKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND 300 301 GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRV 360 361 WFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTY 420 421 TPEP |
| Interface Residues: | 36, 39, 41, 141, 142, 145, 170, 171, 172 |
| 3D-footprint Homologues: | 3iag_C, 5e24_E, 3brd_A |
| Binding Motifs: | 2f8x_C TTCCCACA 3v79_C TGTGGGAA |
| Binding Sites: | 2f8x_X / 3v79_X 2f8x_Y / 3v79_Y |
| Publications: | Nam Y, Sliz P, Song L, Aster J.C, Blacklow S.C. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124:973-83 (2006). [Pubmed] Choi S.H, Wales T.E, Nam Y, O'Donovan D.J, Sliz P, Engen J.R, Blacklow S.C. Conformational locking upon cooperative assembly of notch transcription complexes. Structure (London, England : 1993) 20:340-9 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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