Transcription Factor

						

			
Accessions: KLF1_HUMAN (HOCOMOCO 10), Q13351 (JASPAR 2024)

			
Names: EKLF, Erythroid krueppel-like transcription factor, KLF1_HUMAN, Krueppel-like factor 1
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 362
Pfam Domains:   279-303 Zinc finger, C2H2 type
  280-303 C2H2-type zinc finger
  295-317 Zinc-finger double domain
  309-333 Zinc finger, C2H2 type
  309-333 C2H2-type zinc finger
  326-350 Zinc-finger double domain
  339-361 Zinc finger, C2H2 type
  339-361 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 MATAETALPSISTLTALGPFPDTQDDFLKWWRSEEAQDMGPGPPDPTEPPLHVKSEDQPG   60
  61 EEEDDERGADATWDLDLLLTNFSGPEPGGAPQTCALAPSEASGAQYPPPPETLGAYAGGP  120
 121 GLVAGLLGSEDHSGWVRPALRARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGG  180
 181 YFPRTGLSVPAASGAPYGLLSGYPAMYPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLG  240
 241 PGTVGTGLGGTAEDPGVIAETAPSKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHL  300
 301 RTHTGEKPYACTWEGCGWRFARSDELTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKR  360
 361 HL
Interface Residues: 273, 277, 291, 292, 293, 294, 295, 297, 298, 300, 301, 304, 321, 322, 323, 324, 325, 327, 328, 329, 332, 349, 350, 351, 352, 353, 354, 355, 356, 357, 360
3D-footprint Homologues: 8ssq_A, 7w1m_H, 8ssu_A, 5kkq_D, 6jnm_A, 6ml4_A, 3uk3_C, 8cuc_F, 1tf3_A, 7n5w_A, 2gli_A, 5kl3_A, 1tf6_A, 5ei9_F, 1g2f_F, 7ysf_A, 1ubd_C, 6blw_A, 5k5i_A, 2kmk_A, 1llm_D, 6u9q_A, 8h9h_G, 5v3j_F, 7y3m_I, 6e94_A, 2lt7_A, 6a57_A, 2jpa_A, 7y3l_A, 5yj3_D, 4x9j_A, 1f2i_J, 2wbs_A, 7txc_E, 5yel_A, 2drp_D, 8gn3_A, 4m9v_C
Binding Motifs: KLF1_HUMAN.H10MO.C|M01291 cwGGGTGkGGc
MA0493.2 kGGGyGkGG
MA0493.3 GGGyGkGG
			
Publications: Miller I. J., Bieker J. J. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krueppel family of nuclear proteins. Mol. Cell. Biol. 13:2776-2786 (1993). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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