Transcription Factor
| Accessions: | P53776 (JASPAR 2024) |
| Names: | LHX4_MOUSE, LIM homeobox protein 4, LIM/homeobox protein Lhx4 |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 390 |
| Pfam Domains: | 30-85 LIM domain 89-146 LIM domain 158-214 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MMQSAAVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADC 60 61 QMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIIC 120 121 NRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSP 180 181 KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGGSKQ 240 241 EKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQ 300 301 DLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPT 360 361 SDLSTGSSVGYPDFPTSPASWLDEMDHPPF |
| Interface Residues: | 158, 159, 160, 161, 199, 200, 202, 203, 206, 207, 210, 211, 214, 246 |
| 3D-footprint Homologues: | 1puf_A, 5zjt_E, 2h1k_B, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 2d5v_B, 5flv_I, 3l1p_A, 7psx_B, 3a01_E, 6ryd_F, 1au7_A, 5hod_A, 1puf_B, 7q3o_C, 2hdd_A, 6wig_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 8g87_X, 4qtr_D, 4xrm_B, 1o4x_A, 1du0_A, 7n8n_B |
| Binding Motifs: | MA0704.1 yTAATTAr PH0094.1 kaaaCTAATTAGstwtg MA0704.2 TAATTA |
| Publications: | Noyes M.B, Christensen R.G, Wakabayashi A, Stormo G.D, Brodsky M.H, Wolfe S.A. Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites. Cell 133:1277-89 (2008). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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