Transcription Factor

						

			
Accessions: 1b3t_A (3D-footprint 20231221), 1b3t_B (3D-footprint 20231221), 6pw2_A (3D-footprint 20231221), 6pw2_B (3D-footprint 20231221), 6pw2_C (3D-footprint 20231221), 6pw2_D (3D-footprint 20231221), 6pw2_I (3D-footprint 20231221), 6pw2_J (3D-footprint 20231221), 6pw2_K (3D-footprint 20231221), 6pw2_L (3D-footprint 20231221)

			
Names: EBNA-1, EBNA1_EBVB9, EBV nuclear antigen 1, Epstein-Barr nuclear antigen 1, NUCLEAR PROTEIN EBNA1
Organisms: Epstein-Barr virus (strain B95-8) (HHV-4), Human herpesvirus 4
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P03211
Length: 147
Pfam Domains:     1-146 Epstein Barr virus nuclear antigen-1, DNA-binding domain
Sequence: 
(in bold interface residues)		   1 KGGWFGKHRGQGGSNPKFENIAEGLRALLARSHVERTTDEGTWVAGVFVYGGSKTSLYNL   60
  61 RRGTALAIPQCRLTPLSRLPFGMAPGPGPQPGPLRESIVCYFMVFLQTHIFAEVLKDAIK  120
 121 DLVMTKPAPTCNIRVTVCSFDDGVDLP
Interface Residues: 1, 4, 5, 9, 17, 54, 55, 58, 59, 62
3D-footprint Homologues: 5t7x_B, 7u1t_B
Binding Motifs: 1b3t_A GCTTCCC
1b3t_AB GGGAAGCaTAnGCTTCCC
6pw2_ABCD ATAGCnnnTnTTnCCCnnnGGGnAGmnnnnnCTATC
6pw2_B GATAGca
6pw2_IJKL AATAGCATnTnTTACCCnnnGGGAAGCnnnnGnTAT
Binding Sites: 1b3t_C / 1b3t_D
6pw2_E
6pw2_F
6pw2_G
6pw2_H
			
Publications: Bochkarev A, Bochkareva E, Frappier L, Edwards A.M. The 2.2 A structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1. Journal of molecular biology 284:1273-8 (1998). [Pubmed]


Malecka KA, Dheekollu J, Deakyne JS, Wiedmer A, Ramirez UD, Lieberman PM, Messick TE. Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication. J Virol : (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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