Transcription Factor

						

			
Accessions: NFIC (HT-SELEX2 May2017)

			
Names: ENSG00000141905, NFIC
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: NFI experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: NFI experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 508
Pfam Domains:      5-47 Nuclear factor I protein pre-N-terminus
   70-170 MH1 domain
  217-505 CTF/NF-I family transcription modulation region
Sequence: 
(in bold interface residues)		   1 MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDE   60
  61 LLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDC  120
 121 LRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL  180
 181 AYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVV  240
 241 TGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYY  300
 301 TSPSSPTSSSRNWTEDMEGGISSPVKKTEMDKSPFNSPSPQDSPRLSSFTQHHRPVIAVH  360
 361 SGIARSPHPSSALHFPTTSILPQTASTYFPHTAIRYPPHLNPQDPLKDLVSLACDPASQQ  420
 421 PGPLNGSGQLKMPSHCLSAQMLAPPPPGLPRLALPPATKPATTSEGGATSPTSPSYSPPD  480
 481 TSPANRSFVGLGPRDPAGIYQAQSWGDG
Interface Residues: 40, 43, 44, 48, 250, 251
3D-footprint Homologues: 2lkx_A, 8dc2_A
Binding Motifs: NFIC_2 sTTGGCrysgTGCCArs
NFIC_methyl_1 gtTGGCrygrtGCCArs
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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