Transcription Factor
| Accessions: | 5nj8_B (3D-footprint 20231221) |
| Names: | ARNT protein, ARNT_HUMAN, Aryl hydrocarbon receptor nuclear translocator, bHLHe2, Class E basic helix-loop-helix protein 2, Dioxin receptor, nuclear translocator, HIF-1-beta, HIF1-beta, Hypoxia-inducible factor 1-beta |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P27540 |
| Length: | 174 |
| Pfam Domains: | 7-53 Helix-loop-helix DNA-binding domain 68-133 PAS fold |
| Sequence: (in bold interface residues) | 1 DKERLARENHSEIERRRRNKMTAYITELSDMVPTCPDKLTILRMAVSHMKSLRGSYKPSF 60 61 LTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV 120 121 DKLREQLSTSSRRSFICRMRCHFVVVHCTGYIKAWPDDDPEAKFCLVAIGRLQV |
| Interface Residues: | 7, 9, 10, 11, 13, 14, 17, 18, 36, 38 |
| 3D-footprint Homologues: | 1a0a_B, 1an4_A, 1am9_A, 7ssa_L, 5nj8_D, 4h10_B, 8osl_O, 6g1l_A, 5gnj_I, 5sy7_B, 4zpk_A, 7d8t_A, 5i50_B, 7xi3_A, 5v0l_A, 4zpk_B, 7rcu_E, 4h10_A, 4zpr_B, 8osl_P, 2ypa_A, 5nj8_C, 7xhv_B, 7xi3_B, 5v0l_B |
| Binding Motifs: | 5nj8_AB TtgCGTGA |
| Binding Sites: | 5nj8_E 5nj8_F |
| Publications: | Schulte KW, Green E, Wilz A, Platten M, Daumke O. Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation. Structure 25:1025-1033 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.