Transcription Factor
| Accessions: | UP00155A (UniPROBE 20160601) |
| Names: | H6 homeo box 2, Hmx2, Homeobox protein HMX2, Homeobox protein Nkx-5.2, MGC32455, Nkx5-2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P43687 |
| Description: | H6 homeo box 2 |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 ERPRDGGAERQTGAAKKKTRTVFSRSQVYQLESTFDMKRYLSSSERACLASSLQLTETQV 60 61 KTWFQNRRNKWKRQLSAELEAANMAHASAQTLV |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3d1n_M, 1ig7_A, 5zfz_A, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1nk2_P, 6m3d_C, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 1au7_A, 3a01_E, 5hod_A, 1b72_A, 1ic8_B, 1le8_A, 2xsd_C, 1e3o_C, 4j19_B, 2h8r_B, 7xrc_C, 8g87_X, 1du0_A, 1o4x_A, 1le8_B, 6fqp_B, 1mnm_C, 6fqq_E, 1puf_B, 1k61_B, 4qtr_D |
| Binding Motifs: | UP00155A_1 acaAgCAATTAAwgvrT |
| Binding Sites: | ACAATTAA ACCAATTA AGCAATTA ATAATTGC ATCAATTA ATTAAGTG ATTAATTG CAATTAAA CAATTAAC CAATTAAG CACTTAAA CACTTAAG CCAATTAA CCACTTAA CCGTTTAA GCAATTAA GCACTTAA GGCAATTA TAATTGCA TCAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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