Transcription Factor

						

			
Accessions: 6qhd_B (3D-footprint 20231221)

			
Names: Acute-phase response factor, Signal transducer and activator of transcription 3, STAT3_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P40763
Length: 530
Pfam Domains:     4-174 STAT protein, all-alpha domain
  176-416 STAT protein, DNA binding domain
  426-505 SH2 domain
Sequence: 
(in bold interface residues)		   1 VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGSVTRQKMQQLEQ   60
  61 MLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLEN  120
 121 WITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVER  180
 181 QPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFN  240
 241 ILGTNTKVMNMEESNNGSLSAEFKHLTLREQRASLIVTEELHLITFETEVYHQGLKIDLE  300
 301 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST  360
 361 TKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILA  420
 421 LWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVETQIQSVEPYTKQQ  480
 481 LNNMSFAEIIMGYKIILVSPLVYLYPDIPKEEAFGYCRAPLKTKFICVTP
Interface Residues: 195, 310, 311, 312, 313, 314
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 6qhd_AB TTACsGGAA
Binding Sites: 6qhd_C
6qhd_D
			
Publications: Belo Y, Mielko Z, Nudelman H, Afek A, Ben-David O, Shahar A, Zarivach R, Gordan R, Arbely E. Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj 1863:1343-1350 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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