Transcription Factor

						

			
Accessions: PHOX2B_full (HumanTF 1.0)

			
Names: NBPhox, Neuroblastoma Phox, Paired mesoderm homeobox protein 2B, Paired-like homeobox 2B, PHOX2B, PHOX2B homeodomain protein, PHX2B_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q99453
Notes: Ensembl ID: ENSG00000109132; Full protein sequence; TF family: homeodomain; Clone source: hORFeome
Length: 315
Pfam Domains:    99-155 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSL   60
  61 TPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAET  120
 121 HYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSR  180
 181 DDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGG  240
 241 AAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQR  300
 301 PNGAKAALVKSSMF*
Interface Residues: 98, 99, 100, 101, 102, 140, 141, 143, 144, 147, 148, 151, 152, 155
3D-footprint Homologues: 1nk2_P, 4j19_B, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 5zfz_A, 1fjl_B, 3lnq_A, 1jgg_B, 2lkx_A, 1zq3_P, 2ld5_A, 6es3_K, 7q3o_C, 5hod_A, 7psx_B, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 4cyc_A, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 3a01_E, 1e3o_C, 1le8_A, 6wig_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X
Binding Motifs: PHOX2B_full TAAyyyAATTA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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